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I9032
Interferon β from mouse
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Synonim(y):
IFN β
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Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
rekombinowane
expressed in E. coli
Próba
≥95%
Formularz
buffered aqueous solution
masa cząsteczkowa
~20 kDa
opakowanie
pkg of 1 vial
stężenie
2560000 units/mL
metody
cell culture | mammalian: suitable
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−70°C
informacje o genach
mouse ... Ifnb1(15977)
Opis ogólny
IFN β (interferon β) is from the type 1 interferon family of cytokines.[1]
Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.[2]
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.[3]
Zastosowanie
Interferon β from mouse has been used:
- in the stimulation of bone marrow-derived dendritic cells (BMDCs)[4]
- as a cytokine to stimulate differentiation of podocytes[5]
- to stimulate splenocytes[6]
Interferon ß from mouse has been used:
- to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages[4]
- to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ [7]
- to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)[8]
- as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)[9]
Działania biochem./fizjol.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response.[10] It is also important for anti-inflammatory effects.[1]
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α).[11] It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor.[11] IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression.[11] It has therapeutic potential in treating rheumatoid arthritis[11] and relapsing-remitting multiple sclerosis (MS).[12]
Postać fizyczna
Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.
Komentarz do analizy
The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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