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I8898

Sigma-Aldrich

Ivermectin

Synonim(y):

22,23-Dihydroavermectin B1, MK-933

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250 MG
283,00 zł
1 G
839,00 zł

283,00 zł

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250 MG
283,00 zł
1 G
839,00 zł

About This Item

Numer CAS:
70288-86-7
Numer MDL:
MFCD00869511
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24278497
NACRES:
NA.77

283,00 zł

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Formularz

powder

Poziom jakości

100

rozpuszczalność

MEK: 50 mg/mL

spektrum działania antybiotyku

parasites

Zastosowanie

agriculture
environmental

Tryb działania

cell membrane | interferes

inicjator

Merck & Co., Inc., Kenilworth, NJ, U.S.

temp. przechowywania

2-8°C

ciąg SMILES

[H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC

InChI

1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

Klucz InChI

AZSNMRSAGSSBNP-XPNPUAGNSA-N

informacje o genach

human ... ABCB1(5243) , CYP3A4(1576)
mouse ... Abcb1a(18671) , Abcb1b(18669)

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Opis ogólny

Ivermectin is a macro-cyclic lactone,[1] derived from avermectin.[2] It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.[2]

Zastosowanie

Ivermectin has been used:
  • in Caenorhabditis elegans fecundity assay[3]
  • in larval development test[4]
  • to measure in vivo topical acaricide activity of compounds in rats[5]
  • to assess its acute and chronic effects to zebrafish[6]
  • in percutaneous drug injection method to treat cystic echinococcosis[7]
  • in liquid chromatography with fluorescence detection method[8]

Działania biochem./fizjol.

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Cechy i korzyści

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Inne uwagi

Primarily ivermectin B1a.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300,H311,H351,H360D,H410

Zwroty wskazujące środki ostrożności

P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312

Klasyfikacja zagrożeń

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCV0451
MKCM8215
MKCM4277
MKCK0618
MKCC9996

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Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

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Claire L McArthur et al.
Veterinary parasitology, 212(3-4), 292-298 (2015-06-30)
Cyathostomins are the most prevalent parasitic pathogens of equids worldwide. These nematodes have been controlled using broad-spectrum anthelmintics; however, cyathostomin resistance to each anthelmintic class has been reported and populations insensitive to more than one class are relatively commonplace. The
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Two of three major types of anthelminitic, the avermectins and the nicotinic agonists, exert their therapeutic effect by an action on ligand-gated membrane ion-channels of nematodes. The avermectins, such as ivermectin, open glutamategated chloride channels which have so far been
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Questions

1–6 of 6 Questions  

  1. Is product I8898, Ivermectin the analytical standard grade level? if not, what level is it?

    1 answer

    1. This product is considered a research grade with an assigned quality level of 100. Other Ivermectin products available are primary or secondary pharmaceutical reference standards. Please see the link below to review additional information regarding product quality levels:
      https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program

      Please see the following link to review alternative Ivermectin standard product options:
      https://www.sigmaaldrich.com/search/ivermectin-standard?focus=products&page=1&perpage=30&sort=relevance&term=ivermectin%20standard&type=product

      Helpful?

  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  3. What is the composition of the submoieties B1A and B1B in Product No. I8898, Ivermectin?

    1 answer

    1. Unfortunately we do not test each lot to determine the composition.  In the past, lots have been ~95% B1A and ~5% B1B; however there will be lot-to-lot variation.

      Helpful?

  4. What is the solution stability of Ivermectin (Product No. I8898)?

    1 answer

    1. Stock solutions of Ivermectin in DMSO at a concentration of 10 mM have been found to be stable for 2 weeks at -20°C, according to Shan, Q., et al., in Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel.  J. Biol. Chem., 276(16), 12556-12564 (2001).

      Helpful?

  5. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  6. What is the molecular weight of Product No. I8898, Ivermectin?

    1 answer

    1. This product is a mixture of two submoieties B1A, MW 891.1 and B1B, MW 877.1. It is typically predominantly B1A, so you may use a molecular weight of 890 in your calculations.

      Helpful?

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