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I4770
Anti-Interleukin-9 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Synonim(y):
Anti-IL-9
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About This Item
białko sprzężone:
unconjugated
application:
Neutral
klon:
polyclonal
reaktywność gatunkowa:
human
citations:
8
metody:
neutralization: suitable
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pochodzenie biologiczne
goat
białko sprzężone
unconjugated
forma przeciwciała
IgG fraction of antiserum
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
lyophilized powder
reaktywność gatunkowa
human
metody
neutralization: suitable
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... IL9(3578)
Opis ogólny
Interleukin-9 (IL-9) is a pleotropic cytokine produced by activated T cells and also by mast cells in response to LPS and IL-1. The production of IL-9 is amplified by TGF-β, IL-2 and IL-25. The biological effects of IL-9 are mediated by IL-9 receptor (IL-9R) that is made up of an α and a γ chain. IL-9 signalling results in the activation of major signalling pathways involving STAT1, -3 and -5, MAPK, PI3K and IRS. IL-9 is a pro-inflammatory cytokine and promotes allergic inflammation and airway remodelling in lungs. It also is important in cell growth and differentiation of T cells, B cells, mast cells, hematopoietic progenitors, epithelial cells and airway smooth muscle cells
Monoclonal Anti-Human Interleukin-9 recognizes human IL-9. It does not neutralize the activity of recombinant mouse IL-9. In ELISA and immunoblotting, it shows 20% cross reactivity with mouse IL-9.
Monoclonal Anti-Human Interleukin-9 recognizes human IL-9. It does not neutralize the activity of recombinant mouse IL-9. In ELISA and immunoblotting, it shows 20% cross reactivity with mouse IL-9.
Specyficzność
The antibody neutralizes the biological activity of recombinant human IL-9, but not recombinant mouse IL-9.
Immunogen
recombinant human IL-9 expressed in Sf 21 insect cells.
Zastosowanie
Anti-Interleukin-9 antibody may be used for immunoblotting at a working concentration of 1.0 μg/ml. For ELISA a concentration of 0.5 μg/ml is recommended. The antibody is also suitable for neutralization reactions.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Uwaga dotycząca przygotowania
Purified using protein G.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Certyfikaty analizy (CoA)
Lot/Batch Number
Przepraszamy, ale COA dla tego produktu nie jest aktualnie dostępny online.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Ulla-Angela Temann et al.
The Journal of clinical investigation, 109(1), 29-39 (2002-01-10)
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma. The constitutive overexpression of IL-9 in the lungs of transgenic mice resulted in an asthma-like phenotype. To define the contribution of
Ritobrata Goswami et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3283-3288 (2011-03-04)
IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A
Jennifer Kearley et al.
American journal of respiratory and critical care medicine, 183(7), 865-875 (2010-10-26)
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting
J H Bauer et al.
The Journal of biological chemistry, 273(15), 9255-9260 (1998-05-16)
Interleukin-9 (IL-9) is a cytokine with pleiotropic effects on mast cell and T cell lines. It exerts its effects through the IL-9R complex consisting of IL-9Ralpha and the common gammac subunit. Here we report functional evidence for receptor heteromerization for
J C Renauld et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(12), 5690-5694 (1992-06-15)
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9. Transient expression
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