HPA043237
Anti-APOBEC3A antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonim(y):
Anti-Apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3a, Anti-Arp3, Anti-Phrbn
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About This Item
Kod UNSPSC:
12352203
Numer w atlasie ludzkich białek:
Polecane produkty
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
linia produktu
Prestige Antibodies® Powered by Atlas Antibodies
Postać
buffered aqueous glycerol solution
reaktywność gatunkowa
human
rozszerzona walidacja
recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
metody
immunohistochemistry: 1:1000-1:2500
western blot: 0.04-0.4 μg/mL
sekwencja immunogenna
EASPASGPRHLMDPHIFTSNFNNGIGR
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... APOBEC3A(200315)
Opis ogólny
The gene APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is mapped to human chromosome 22q13.1. The protein has a catalytically active deaminase domain. It belongs to the APOBEC3 genes family.
Immunogen
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A recombinant protein epitope signature tag (PrEST)
Zastosowanie
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-APOBEC3A antibody produced in rabbit has been used in immunohistochemistry.
Anti-APOBEC3A antibody produced in rabbit has been used in immunohistochemistry.
Anti-APOBEC3A antibody produced in rabbit has also been used in immunofluorescence staining.
Działania biochem./fizjol.
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) is a cytidine deaminase. APOBEC3 proteins are mainly involved in intracellular antiviral defense responses, particularly against retroviruses. They are also involved in carcinogenesis by dC (deoxycytidine) deamination, thereby causing DNA mutations. APOBEC3A also exhibits mRNA-editing function. It is involved with guanine-to-alanine editing in transcripts of WT1 (wilms tumor 1). Deletion in APOBEC3A gene is associated with breast cancer predisposition. This happens due to increased stability of APOBEC3A mRNA.
Cechy i korzyści
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Powiązanie
Corresponding Antigen APREST83236
Postać fizyczna
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Informacje prawne
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.
Kondo S, et al.
Oncogene, doi: 10-doi: 10 (2016)
Makoto Kano et al.
International journal of cancer, 145(6), 1547-1557 (2019-06-23)
Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide
Activation of DNA damage repair factors in HPV positive oropharyngeal cancers
Kono T, et al.
Virology (2020)
Pavla Brachova et al.
Gynecologic oncology, 145(3), 577-583 (2017-02-22)
Ovarian carcinomas that originate from fallopian epithelial cells are suggested to arise due to repeated exposure to ovulatory follicular fluid (FF). Mechanistic explanation(s) for how this occurs are unknown. Here, we sought to understand if FF exposure to fallopian epithelial
Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.
Marouf C, et al.
BMC Cancer, 16, 165-165 (2016)
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