GW10817F
Anti-TAT antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-Protein Tat, Anti-Transactivating regulatory protein
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
chicken
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
producent / nazwa handlowa
Genway 15-288-10817F
metody
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... tat(155871)
Powiązane kategorie
Immunogen
Immunogen Sequence: GI # 9629358, sequence 1-86
Recombinant tat (human immunodeficiency virus 1)
Zastosowanie
Anti-TAT antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Działania biochem./fizjol.
TAT (Transactivating regulatory protein) is a trans-activator of human immunodeficiency virus-1 (HIV-1) gene expression and is important for virus replication. It binds to the bulge loop RNA element called TAR, but can also associate with cellular transcription factors. Cyclin T binds with TAT and thereby enhances the affinity of TAT-TAR RNA interaction. Protein arginine methyltransferase-6 (PRMT6) is responsible for methylation of TAT and negatively affects the association between TAT and cyclin T. TAT is involved in the activation of nuclear factor κB (NFκB), a master regulator of pro-inflammatory genes. TAT binds with α5β1 and αvβ3 integrins, and causes vascular cell migration and invasion. At the neural plasma membrane, TAT induces formation of a complex involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), N-methyl-d-aspartic acid (NMDA) receptors and neuronal nitric oxide synthase (nNOS). This complex is responsible for apoptosis in neurons and astrocytes, causing neurologic dysfunction in AIDS patients.
Postać fizyczna
Solution in phosphate buffered saline containing 0.02% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Giuseppe Fiume et al.
Nucleic acids research, 40(8), 3548-3562 (2011-12-22)
Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection. Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS. We report that in single round
R A Marciniak et al.
The EMBO journal, 10(13), 4189-4196 (1991-12-01)
The Tat protein of HIV-1 trans-activates transcription in vitro in a cell-free extract of HeLa nuclei. Quantitative analysis of the efficiency of elongation revealed that a majority of the elongation complexes generated by the HIV-1 promoter were not highly processive
Baode Xie et al.
Journal of virology, 81(8), 4226-4234 (2007-02-03)
Arginine methylation has been shown to regulate signal transduction, protein subcellular localization, gene transcription, and protein-protein interactions that ultimately alter gene expression. Although the role of cellular protein arginine methyltransferases (PRMT) in viral gene expression is largely unknown, we recently
G Barillari et al.
Blood, 94(2), 663-672 (1999-07-09)
The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi's sarcoma (KS) development in infected individuals. In this study, we investigated
Eliseo A Eugenin et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(9), 3438-3443 (2007-03-16)
HIV infection of the central nervous system can result in neurologic dysfunction with devastating consequences in AIDS patients. NeuroAIDS is characterized by neuronal injury and loss, yet there is no evidence that HIV can infect neurons. Here we show that
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