G8377

Guanosine 5′-monophosphate disodium salt hydrate

Name: Guanosine 5&#8242;-monophosphate disodium salt hydrate
Brand: SIGMA
Price: 225 PLN

≥99%,from yeast, powder

Synonim(y):

5′-GMP-Na₂, 5′-Guanylic acid disodium salt hydrate

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Wybierz wielkość

500 MG

225,00 zł

1 G

339,00 zł

5 G

480,00 zł

25 G

1950,00 zł

100 G

5830,00 zł

225,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₀H₁₂N₅Na₂O₈P · xH₂O

Numer CAS:

5550-12-9

Masa cząsteczkowa:

407.18 (anhydrous basis)

NACRES:

NA.51

PubChem Substance ID:

24895338

UNSPSC Code:

41106305

EC Number:

226-914-1

MDL number:

MFCD00151238

Beilstein/REAXYS Number:

3586801

Assay:

≥99%

Biological source:

yeast

Form:

powder

Solubility:

H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow

Storage temp.:

room temp

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Nazwa produktu

Guanosine 5′-monophosphate disodium salt hydrate, from yeast, ≥99%

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI key

MEKWJTZTMVQYSU-CYCLDIHTSA-L

SMILES string

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

biological source

yeast

assay

≥99%

form

powder

solubility

H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

Powiązane kategorie

Biochemicals

Nucleosides and Nucleotides

Phosphates

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Ta pozycja	G6129	I4625	852228
Sigma-Aldrich G8377 Guanosine 5′-monophosphate disodium salt hydrate	Sigma-Aldrich G6129 Guanosine 3′,5′-cyclic monophosphate sodium salt	Sigma-Aldrich I4625 Inosine 5′-monophosphate disodium salt hydrate	Sigma-Aldrich 852228 2′-Deoxyguanosine 5′-monophosphate disodium salt hydrate
biological source yeast	biological source -	biological source yeast	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
form powder	form powder	form powder	form solid
assay ≥99%	assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥98%
solubility H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow	solubility H₂O: 50 mg/mL	solubility water: 50 mg/mL, clear, colorless	solubility -
storage temp. room temp	storage temp. −20°C	storage temp. 2-8°C	storage temp. -

Application

Guanosine 5′-monophosphate is suitable for use in:

the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure[1]
the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes[2]
the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS[3]

Biochem/physiol Actions

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Klasa składowania

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ].

Robbin R Vernooij et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)

The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and

Systemic administration of GMP induces anxiolytic-like behavior in rats.

Roberto Farina Almeida et al.

Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)

The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the

Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex.

Marcelo Ganzella et al.

Purinergic signalling, 8(1), 49-58 (2011-09-02)

Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered

NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain.

Bing Wang et al.

Nucleic acids research, 49(15), 8822-8835 (2021-08-06)

The catalytic subunit of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) contains two active sites that catalyze nucleotidyl-monophosphate transfer (NMPylation). Mechanistic studies and drug discovery have focused on RNA synthesis by the highly conserved RdRp. The second active site, which resides in

Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts.

Hans F N Kvitvang et al.

Journal of chromatography. A, 1370, 70-79 (2014-12-03)

Metabolic profiling has become an important tool in biological research, and the chromatographic separation of metabolites coupled with mass spectrometric detection is the most frequently used approach for such studies. The establishment of robust chromatographic methods for comprehensive coverage of

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Protokoły

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

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Guanosine 5′-monophosphate disodium salt hydrate