G3381

Geldanamycin from Streptomyces hygroscopicus

from Streptomyces hygroscopicus, ≥98% (HPLC), Nuclear hormone receptor inhibitor, powder

• Synonim(y): NSC 122750
• Wzór empiryczny (zapis Hilla): C₂₉H₄₀N₂O₉
• Numer CAS: 30562-34-6
• Masa cząsteczkowa: 560.64
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799914
• NACRES: NA.77
• MDL number: MFCD00274570
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC), powder
• sterility: non-sterile
• Quality Segment: 300
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI key: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Opis

General description

Chemical structure: benzenoid

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Features and Benefits

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)