Upon verification, D3695 is known to induce hypoxia. For further reference, you can refer the following citation: "Biomed Pharmacother. 2020 Jan;121:109606. doi: 10.1016/j.biopha.2019.109606. Epub 2019 Nov 25. Prodrug of epigallocatechin-3-gallate alleviates choroidal neovascularization via down-regulating HIF-1α/VEGF/VEGFR2 pathway and M1 type macrophage/microglia polarization."
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D3695
DMOG
≥98% (HPLC), powder, HIF-hydroxylase inhibitor
Synonim(y):
Dimethyloxalylglycine, N-(Methoxyoxoacetyl)-glycine methyl ester
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10 MG
552,00 zł
50 MG
1840,00 zł
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10 MG
552,00 zł
50 MG
1840,00 zł
About This Item
Wzór empiryczny (zapis Hilla):
C6H9NO5
Numer CAS:
Masa cząsteczkowa:
175.14
Numer MDL:
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
NACRES:
NA.77
552,00 zł
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Polecane produkty
Nazwa produktu
DMOG, ≥98% (HPLC)
Poziom jakości
Próba
≥98% (HPLC)
Formularz
powder
kolor
white to off-white
rozpuszczalność
H2O: >30 mg/mL
Warunki transportu
wet ice
temp. przechowywania
−20°C
ciąg SMILES
COC(=O)CNC(=O)C(=O)OC
InChI
1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
Klucz InChI
BNJOZDZCRHCODO-UHFFFAOYSA-N
Zastosowanie
DMOG has been used:
- in hypoxia-inducible factor (HIF) activity assay[1]
- to examine its effects on the degradation of HIF-1α and renal regeneration[2]
- in DMOG preconditioning of adipose tissues[3]
- as vehicle control for the primary liquid culture of CD34+ cells[4]
- for endothelial cell stimulation[5]
Dimethyloxalylglycine (DMOG) has been used as an inhibitor of ten-eleven translocation 3 (TET3) protein.[6]
Działania biochem./fizjol.
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor).
DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). The protein level of HIF-1α subunit is post-transcriptionally regulated by prolyl and asparaginyl hydroxylase (PAH). Suppression of PAH activity increases endogenous HIF-1α levels. DMOG is a cell permeable, competitive inhibitor of prolyl hydroxylase domain-containing proteins (PHDs and HIF-PHs). It has been discovered that the DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model. DMOG is more potent than the older inhibitor 4-Phenyl-pyridine-2,5-dicarboxylic acid (R395889; Sigma-Aldrich rare chemicals library). The IC50 is 5.18 μM.
Cechy i korzyści
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 4 Oral
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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Is it suitable to use D3695 to induce hypoxia?
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Bonjour, Quelle est la durée de conservation à -20°C de ce réactif ? Merci
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This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment.
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