C7117
Anti-Cullin-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-Cul1
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Postać
buffered aqueous solution
masa cząsteczkowa
antigen 85 kDa
reaktywność gatunkowa
human, mouse
metody
western blot: 0.5-1 μg/mL using whole cell extract of human colon carcinoma HCT-116 cell line and whole cell extract of mouse fibroblasts NIH3T3 cell line
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... CUL1(8454)
mouse ... Cul1(26965)
Opis ogólny
Cullin-1 (Cul1) is encoded by the gene mapped to human chromosome 7q36.1. It is a 85 kDa protein that belongs to the family of cullin protein family containing distinct group of mediators (at least eight cullin members Cul1-8).
Immunogen
synthetic peptide located at the C-terminus of human cullin-1 (amino acids 759-776). This sequence is identical in mouse cullin-1 and highly conserved (83% identity) in Drosophila cullin-1.
Zastosowanie
Anti-Cullin-1 antibody produced in rabbit has been used in western blotting.
Działania biochem./fizjol.
Cullin 1(CUL1) is a scaffold protein of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex, which ubiquitinates a broad range of proteins that are involved in cell-cycle progression, signal transduction and transcription. Cul1 plays an important role in protein degradation and protein ubiquitination. It regulates breast cancer cell proliferation, migration and invasion. Overexpression of Cul1 leads to breast cancer progression. CUL1 promotes human trophoblast cell invasion and dysregulation of its expression may be associated with pre-eclampsia (PE). It may have some role in rheumatoid arthritis (RA) and its response to methotrexate. Cullin1 may act as an important marker for human gastric cancer lymph node metastasis and prognosis.
Postać fizyczna
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Cullin-1 regulates MG63 cell proliferation and metastasis and is a novel prognostic marker of osteosarcoma
Cheng Q and Yin G
The International Journal of Biological Markers, 32(2), 202-209 (2017)
J Bai et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 24(8), 2016-2022 (2013-04-18)
To investigate the role of Cullin1 (Cul1) in the development of breast cancer, we examined the expression of Cul1 in breast cancer tissues and analyzed the correlation between Cul1 expression and clinicopathologic variables and patients survival. We evaluated the Cul1
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels
Korzeniewski N, et al.
Cancer research, 69(16), 6668-6675 (2009)
Jin Bai et al.
Human pathology, 42(3), 375-383 (2010-12-31)
Cullin1 (Cul1) is a scaffold protein of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex, which ubiquitinates a broad range of proteins involved in cell-cycle progression, signal transduction, and transcription. To investigate the role of Cullin1 in the development of gastric
Q Zhang et al.
Cell death & disease, 4, e502-e502 (2013-02-23)
Human trophoblast progenitor cells differentiate via two distinct pathways, to become the highly invasive extravillous cytotrophoblast (CTB) cells (EVT) or fuse to form syncytiotrophoblast. Inadequate trophoblast differentiation results in poor placenta perfusion, or even complications such as pre-eclampsia (PE). Cullin1
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