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C5749
CGP 52608
≥98%, RORA activator, solid
Synonym(s):
1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone, N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $170.00 $144.50 |
25 mg | Available to ship TODAYfromMILWAUKEE | $668.00 |
About This Item
Empirical Formula (Hill Notation):
C8H12N4OS2
CAS Number:
Molecular Weight:
244.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98%
Form:
solid
$144.50
List Price$170.00Save 15%Web-Only Promotion
Available to ship TODAYDetails
Product Name
CGP 52608, ≥98%, solid
assay
≥98%
form
solid
solubility
DMSO: >30 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
CNC(=S)N\N=C1/SCC(=O)N1CC=C
InChI
1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-
InChI key
DDYJDIHOSRTMSE-FLIBITNWSA-N
Application
Biochem/physiol Actions
CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).
CGP 52608 is a thiazolidine derivative[4] and an antiarthritic compound.[5] It possesses immunostimulatory functionality[4] and elicits antiproliferative effect in colon tumors.[6] It is cytotoxic towards neural cell lines.[5] CGP 52608 induces apoptosis in tumor[6] and also favors G0-G1 cell cycle phase accumulation in neural cell lines.[5]
Features and Benefits
This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: >30 mg/mL, H2O: insoluble | solubility DMSO: 15 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hi, I wonder how long time I can use it the CGP52608 (C5749) after delivery since there is no expiry date on the CoA ?
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