C4542

Cyclobenzaprine hydrochloride

• Synonim(y): 5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₀H₂₁N · HCl
• Numer CAS: 6202-23-9
• Masa cząsteczkowa: 311.85
• Numer WE: 228-264-4
• Numer MDL: MFCD00079039
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24278315
• NACRES: NA.77

Właściwości

• Formularz: powder
• Poziom jakości: 200
• inicjator: Johnson & Johnson
• ciąg SMILES: Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13
• InChI: 1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
• Klucz InChI: VXEAYBOGHINOKW-UHFFFAOYSA-N
• informacje o genach: human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Opis

Opis ogólny

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties.[1] It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of noradrenaline. It is used to treat neck, back and myofascial pain.[2] Cyclobenzaprine functions as a nerve impulse inhibitor.[3]

Zastosowanie

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.[4]

Cyclobenzaprine hydrochloride has been used to study its effects on the muscles of dystrophin-deficient mdx5Cv mice.[4]

Działania biochem./fizjol.

Cyclobenzaprine hydrochloride is a type of tricyclic skeletal drug,[5] which is commonly used as a muscle relaxant.[6][5] It is very effective in treating intractable pain of cervical and lumbar origin caused by skeletal muscle spasm.[5] cyclobenzaprine hydrochloride inhibit tonic α-mononeuronal excitation mediated by descending serotonergic systems by interacting with serotonin receptors at the spinal cord level.[7]

Skeletal muscle relaxant; 5-HT₂ serotonin receptor antagonist.

Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT₂ serotonin receptor antagonist.

Cechy i korzyści

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H312 + H332
• Zwroty wskazujące środki ostrożności: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves