A6706

O-Acetyl-L-carnitine hydrochloride

≥99% (titration)

• Synonim(y): Acetyl L-carnitine HCl, (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride, ALC, ALCAR, R-(−)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride
• Wzór empiryczny (zapis Hilla): C₉H₁₇NO₄ · HCl
• Numer CAS: 5080-50-2
• Masa cząsteczkowa: 239.70
• Beilstein: 4340103
• Numer MDL: MFCD00082230
• Kod UNSPSC: 12352204
• Identyfikator substancji w PubChem: 24891132
• NACRES: NA.83

Właściwości

• Nazwa produktu: O-Acetyl-L-carnitine hydrochloride, ≥99% (titration), powder
• pochodzenie biologiczne: synthetic
• Poziom jakości: 300
• Próba: ≥99% (titration)
• Formularz: powder
• aktywność optyczna: [α]25/D −28°, c = 2 in H₂O(lit.)
• kolor: white to off-white
• mp: 194 °C
• rozpuszczalność: H₂O: 100 mg/mL
• Zastosowanie: cell analysis
• temp. przechowywania: 2-8°C
• ciąg SMILES: C[N+](C)(C)C[C@H](OC(C)=O)CC(O)=O.[Cl-]
• InChI: 1S/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/m1./s1
• Klucz InChI: JATPLOXBFFRHDN-DDWIOCJRSA-N

Opis

Opis ogólny

Acetyl-L-carnitine (ALC/ALCAR), a quasi-vitamin[1] is a metabolite of carnitine, present in mammalian plasma and tissues.[2] It is the acetylated form of L-carnitine (LC).[1] ALCAR is used as a dietary supplement.[2] It is present at high level in the hypothalamus.[1]

Zastosowanie

O-Acetyl-L-carnitine hydrochloride has been used:

• as a bioactive compound to study its effect on the proliferation of B-lymphoblastoid cell lines (BLCL) and its immune modulating properties on influenza virus specific human B and T cell responses in vitro[3]
• as in vitro maturation (IVM) media component to study its effects on lamb oocyte blastocyst rate, ultrastructure and mitochondrial DNA copy number[4]
• as a metabolite/chemical standard to quantify the metabolite levels in murine tumor interstitial fluid[5]

Działania biochem./fizjol.

Acetyl _L-carnitine (ALC) plays a vital role in intermediary metabolism and in improving female fertility. The oxidative and metabolic status of the female reproductive system is controlled by ALC. ALC possesses cholinomimetic[1] and anti-inflammatory effects.[2] It controls γ-amino butyric acid (GABA) system.[1] ALC is capable of modifying the rate of glucose usage in the brain. It also possesses a neuroprotective role in the developing brain.[2]

Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane.

Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves