The difference between the Type I and Type II Asialofetuin products does not represent any kind of biochemical or functional difference. These indicate different methods of production and purification. The Type II option, product A1908, utilizes neuraminadase in an enzymatic cleavage step. The Type I, product A4781, utilizes a proprietary modification of that described in Spiro, R.G., J. Biol. Chem., 235, 2860 (1960).
A1908
Asialofetuin from fetal calf serum
Type II (Sigma designation)
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50 MG
3240,00 zł
3240,00 zł
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Pozwól nam pomócNazwa produktu
Asialofetuin from fetal calf serum, Type II (Sigma designation)
biological source
bovine
type
Type II (Sigma designation)
form
powder
technique(s)
activity assay: suitable
inhibition assay: suitable
impurities
salt, essentially free
≤1.0% N-acetylneuraminic acid
solubility
H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow
storage temp.
2-8°C
Quality Level
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Ta pozycja | A4781 | F2379 | F3004 |
|---|---|---|---|
| biological source bovine | biological source bovine (calf) serum | biological source bovine serum (fetal) | biological source bovine serum (fetal) |
| technique(s) activity assay: suitable, inhibition assay: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, MALDI-MS: suitable |
| form powder | form powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| impurities salt, essentially free, ≤1.0% N-acetylneuraminic acid | impurities salt, essentially free, ≤0.5% N-acetylneuraminic acid | impurities ≤0.3% free N-acetylneuraminic acid | impurities ~0.2% free N-acetylneuraminic acid |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
Application
Asialofetuin from fetal calf serum is suitable for use:
Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.
Biochem/physiol Actions
Preparation Note
Enzymatic cleavage using neuraminidase
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Serum-resistant lipoplexes in the presence of asialofetuin
Liposomes, 2011, 425-434 (2010)
W M Brown et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 14(11), 749-755 (1992-11-01)
Bovine fetuin, the first fetal protein to be described, has recently been shown to be a species homologue of a well known human plasma protein--alpha 2HS glycoprotein (alpha 2HS). The fetuins are now known to be members of the cystatin
In vitro gene delivery mediated by asialofetuin-appended cationic liposomes associated with gamma-cyclodextrin into hepatocytes
Motoyama K, et al.
Journal of Drug Delivery, 2011 (2011)
X C Wang et al.
The Journal of biological chemistry, 264(3), 1854-1859 (1989-01-25)
The hepatic acute phase response is accompanied by increased levels of Gal beta 1-4GlcNAc alpha 2,6-sialyltransferase activity in liver and in circulation. Previous studies suggested that cytokines and glucocorticoids mediate the induction of this sialyltransferase activity. In this study the
A C Schroeder et al.
Biology of reproduction, 43(5), 891-897 (1990-11-01)
The zona pellucida of mouse oocytes becomes resistant to chymotrypsin digestion, or "hardened", when spontaneous maturation occurs in serum-free medium (De Felici and Siracusa, Gam Res 1982; 6:107). The hardened zona pellucida is refractory to sperm penetration, thus preventing fertilization.
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What is the difference in Type 1 versus Type II asialofetuin?
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