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5051

Sigma-Aldrich

Human Vitronectin

from human plasma, liquid, 0.5 mg/mL, suitable for cell culture

Synonim(y):

Cell adhesion protein, ECM protein

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About This Item

Kod UNSPSC:
12352202
NACRES:
NA.75

product name

Vitronectin, from human plasma, suitable for cell culture, solution

pochodzenie biologiczne

human plasma

Poziom jakości

100

sterylność

sterile-filtered

Próba

>95%

Postać

solution

masa cząsteczkowa

75 kDa

opakowanie

pkg of 0.1 mg

stężenie

0.5 mg/mL

metody

cell culture | mammalian: suitable

rozpuszczalność

water: miscible

numer dostępu UniProt

P04004

Warunki transportu

dry ice

temp. przechowywania

−20°C

informacje o genach

human ... VTN(7448)

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Opis ogólny

Vitronectin is a 75 kDa glycoprotein produced by hepatocytes and liberated into the blood. It has four domains and at least two structural motifs. Vitronectin gene is small with three kilobases in length and has eight exons. It is also present on fibers in the extracellular matrices of several tissues.
Vitronectin is a monomeric glycoprotein used to promote cell attachment, migration, proliferation and differentiation in a broad number of cell lines and types. This product has been purified from human plasma where it is found as a mixture of 75kDa and 65kDa polypeptides.

Vitronectin′s primary use in cell culture is related to cell adhesion. It also binds to heparin and collagen.

Vitronectin is ideal for coating of surfaces. The optimal concentration for cell attachment and culture may differ for various cell types. Vitronectin has been used at a final coating concentration as low as 50 ng/cm2 on plasticware. It is provided in user-friendly packaging for use and storage. Vitronectin is sterile filtered and is supplied as a ready to use solution after thawing and concentration adjustment.

Działania biochem./fizjol.

Vitronectin controls proteolysis. It helps in in vitro cell adhesion.Vitronectin is involved in the modulation of perforin mediated killing by cytotoxic T-lymphocytes and natural killer (NK) cells. It controls the inflammatory reactions in blood.

Uwaga dotycząca przygotowania

This product is supplied in a solution of 0.15 M NaCl and 0.005M HEPES at pH 7.4

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Kod klasy składowania

10 - Combustible liquids

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Extracellular Matrix (1996)
The Molecular and Cellular Biology of Wound Repair (2013)
Zayda L Piedra-Quintero et al.
Frontiers in immunology, 9, 3118-3118 (2019-01-29)
Intestinal macrophages are highly mobile cells with extraordinary plasticity and actively contribute to cytokine-mediated epithelial cell damage. The mechanisms triggering macrophage polarization into a proinflammatory phenotype are unknown. Here, we report that during inflammation macrophages enhance its intercellular adhesion properties
Si En Poh et al.
Frontiers in cellular and infection microbiology, 10, 148-148 (2020-04-25)
Malassezia is the most abundant eukaryotic microbial genus on human skin. Similar to many human-residing fungi, Malassezia has high metabolic potential and secretes a plethora of hydrolytic enzymes that can potentially modify and structure the external skin environment. Here we
Augusto Martins Lima et al.
International journal of molecular sciences, 21(18) (2020-09-11)
Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and

Produkty

Białka macierzy zewnątrzkomórkowej i narzędzia do optymalizacji hodowli komórkowej

Białka macierzy zewnątrzkomórkowej, takie jak laminina, kolagen i fibronektyna, mogą być stosowane jako podłoża do mocowania komórek w hodowli komórkowej.

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

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