If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
Przejdź do
PHR2407
N-Nitrosodimethylamine (NDMA)
Pharmaceutical Secondary Standard; Certified Reference Material
Synonim(y):
N-Nitrosodimethylamine, NDMA, Dimethylnitrosamine
Wybierz wielkość
| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 953,00 zł |
Informacje o tej pozycji
953,00 zł
Quality Segment
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1466674
vapor pressure
5 mmHg ( 20 °C)
form
liquid
CofA
current certificate can be downloaded
packaging
pkg of 100 mg
refractive index
n20/D 1.437 (lit.)
bp
153 °C/774 mmHg (lit.)
density
1.01 g/mL (lit.)
application(s)
cosmetics
food and beverages
pharmaceutical
storage temp.
2-8°C
SMILES string
CN(C)N=O
InChI
1S/C2H6N2O/c1-4(2)3-5/h1-2H3
InChI key
UMFJAHHVKNCGLG-UHFFFAOYSA-N
General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. It is analyzed using Pharmacopeial compendial methods and/or validated methods, and is traceable to USP, EP standards where applicable.
It is provided with a comprehensive certificate of analysis (CoA) containing a certified purity value, calculated by the mass balance approach. All information regarding the use of this CRM can be found on the certificate of analysis.
Application
- Determination of N-Nitrosodimethylamine (NDMA) as an impurity in four valsartan APIs and tablets by high-performance liquid chromatography (HPLC)
- Quantitative analysis of NDMA in valsartan pharmaceutical formulations by capillary electrophoresis-nanospray-mass spectrometry
- Simultaneous determination of N-nitrosodimethylamine and N-nitrosomethylethylamine in drug substances and products containing sartans, ranitidine, and metformin by solid-phase extraction (SPE) and gas chromatography-tandem mass spectrometry (GC-MS/MS)
- Analysis of NDMA in the olmesartan API and tablets by high-performance liquid chromatography-mass spectrometry (HPLC-MS)
- Development and validation of an HPLC-MS/MS method for separation and quantification of NDMA impurity for quality control of ranitidine products
Biochem/physiol Actions
Other Notes
1 of 1
Ta pozycja | |||
|---|---|---|---|
| description Pharmaceutical Secondary Standard; Certified Reference Material | description certified reference material, 5000 μg/mL in methanol, ampule of 1 mL | description certified reference material, 200 μg/mL in methanol | description United States Pharmacopeia (USP) Reference Standard |
| grade pharmaceutical secondary standard, certified reference material | grade TraceCERT®, certified reference material | grade TraceCERT®, certified reference material | grade pharmaceutical primary standard |
| application(s) cosmetics | application(s) cleaning products | application(s) cleaning products | application(s) USP Biologics |
| form liquid | form - | form - | form liquid |
| vapor pressure 5 mmHg ( 20 °C) | vapor pressure - | vapor pressure - | vapor pressure - |
| refractive index n20/D 1.437 (lit.) | refractive index - | refractive index - | refractive index - |
| agency traceable to USP 1466674 | agency - | agency EPA TO-7 | agency USP |
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Słowo ostrzegawcze
Danger
Kody zagrożeń
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Carc. 1B - STOT RE 1
Narządy docelowe
Liver
Klasa składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Temperatura zapłonu (°F)
141.8 °F - closed cup
Temperatura zapłonu (°C)
61.0 °C - closed cup
Wykazy regulacyjne
Wykazy regulacyjne dotyczą głównie produktów chemicznych. Można w nich podawać ograniczoną liczbę informacji na temat produktów niechemicznych. Brak wpisu oznacza, że żaden ze składników nie znajduje się w wykazie. Użytkownik odpowiada za zagwarantowanie bezpiecznego i zgodnego z prawem stosowania produktu.
62-75-9
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I bought the PHR2407-100 mg product; however, I can not find information about the liquid in which it was dissolved. Can you please give me that information?
1 answer-
This product is supplied as a neat or pure liquid that has not been diluted in a solvent or buffer. This compound has a density of 1.01 g/mL.
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