61076

DL-4-Hydroxy-2-ketoglutaric acid lithium salt

analytical standard

• Synonim(y): 4-Hydroxy-2-oxoglutaric acid lithium salt, DL-KHG Li
• Wzór empiryczny (zapis Hilla): C₅H₆O₆ · xLi⁺
• Numer CAS: 1187-99-1
• Masa cząsteczkowa: 162.10 (free acid basis)
• Beilstein: 1780096
• Kod UNSPSC: 41116107

Właściwości

• klasa czystości: analytical standard
• Próba: ≥97.0% (HPLC)
• okres trwałości: limited shelf life, expiry date on the label
• Zastosowanie: clinical testing
• format: neat
• temp. przechowywania: −20°C
• InChI: 1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)
• Klucz InChI: WXSKVKPSMAHCSG-UHFFFAOYSA-N

Opis

Opis ogólny

DL-4-Hydroxy-2-ketoglutaric acid lithium salt (HOG) is a precursor substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA1), a unique enzyme in the hydroxyproline catabolism pathway. It is reported that the primary hyperoxaluria type 3, which is a recently discovered form of the autosomal recessive disease, results from the mutations in the gene coding for HOGA1.

Zastosowanie

DL-4-Hydroxy-2-ketoglutaric acid lithium salt may be used as an analytical reference standard for the determination of the analyte in animal biological samples using ion chromatography coupled to negative electrospray mass spectrometry (IC/ES-MS). This can be used to determine the primary hyperoxalurias PH Type 3 (PH3), caused by the mutations in the mitochondrial enzyme, 4-hydroxy-2-oxoglutarate aldolase (HOGA).

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable