SCT066
BioTracker Tau filaments pFTAA Live Cell Dye
Synonim(y):
Live cell imaging probe
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About This Item
Kod UNSPSC:
12171501
NACRES:
NA.32
Polecane produkty
metody
cell based assay: suitable
Opis ogólny
Protein misfolding diseases are characterized by deposition of protein aggregates. Accumulation of protein deposits, so-called amyloid, is the histopathological hallmark of several devastating diseases, and the development of sensitive optical ligands to detect and characterize these disease-associated structures is of great interest.
The BioTracker Tau filaments pFTAA live cell dye is a novel fluorescent probe that can bind to and discriminate between amyloid-b (A?) plaques and tau neurofibrillary tangles (NFTs) in Alzheimer′s disease (AD)-like pathology in transgenic mouse brain tissue sections.
Spectral Properties:
References:
Klingstedt T et al. The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates. Chem Eur J. 2013, 19, 10179-10192.
The BioTracker Tau filaments pFTAA live cell dye is a novel fluorescent probe that can bind to and discriminate between amyloid-b (A?) plaques and tau neurofibrillary tangles (NFTs) in Alzheimer′s disease (AD)-like pathology in transgenic mouse brain tissue sections.
Spectral Properties:
- Excitation: 405 nm
- Emissions: 550 nm
References:
Klingstedt T et al. The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates. Chem Eur J. 2013, 19, 10179-10192.
Zastosowanie
Application: Live cell fluorescent imaging
Live cell imaging dye for detection of disease-associated protein aggregates such as Amyloid protein deposits.
Jakość
Purity: ≥98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 704.65 g/mol
Molar Mass: 704.65 g/mol
Inne uwagi
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
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Kod klasy składowania
13 - Non Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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