Yes, this probe can be used in fixed cells. Please see the following reference:
Chen X et al. Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells. Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4702-4706.
SCT056
BioTracker QUMA-1 RNA G-quadruplex Live Cell Dye
A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
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1 MG
1640,00 zł
1640,00 zł
Przewidywany termin wysyłki05 maja 2025Szczegóły
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1 MG
1640,00 zł
About This Item
Kod UNSPSC:
12352207
NACRES:
NA.47
1640,00 zł
Przewidywany termin wysyłki05 maja 2025Szczegóły
Polecane produkty
Próba
≥98% (H-NMR)
≥98% (HPLC)
≥98% (LC/MS)
≥98% (elemental analysis)
metody
cell based assay: suitable
metoda wykrywania
fluorometric
Opis ogólny
RNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions: telomere elongation, DNA recombination, transcription, RNA post-transcriptional mechanisms (pre-mRNA processing, mRNA turnover, targeting and translation), and are associated with sevral human diseases.
BioTracker<TMSYMBOL></TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.
Spectral Properties
Absorbance: 555 nm
Emission: 660 nm
BioTracker<TMSYMBOL></TMSYMBOL> QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA, double-stranded RNA, single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interactions.
Spectral Properties
Absorbance: 555 nm
Emission: 660 nm
Zastosowanie
A red-emitting fluorescent probe for tracking RNA G-quadruplexes dynamics, such as folding and unfolding, in live cells.
Live cell fluorescent imaging
Research Category
Cell Imaging
microRNA
RNA Metabolism & Binding Proteins
Cell Imaging
microRNA
RNA Metabolism & Binding Proteins
Research Sub Category
Live Cell Dye
Live Cell Dye
Jakość
Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 628.17 g/mol
Molar Mass: 628.17 g/mol
Postać fizyczna
Lyophilized
Przechowywanie i stabilność
Store BioTracker QUMA-1 RNA G-quadruplex -Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Inne uwagi
Concentration: Please refer to lot specific datasheet.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Xiu-Cai Chen et al.
Angewandte Chemie (International ed. in English), 57(17), 4702-4706 (2018-02-18)
Because of the absence of methods for tracking RNA G-quadruplex dynamics, especially the folding and unfolding of this attractive structure in live cells, understanding of the biological roles of RNA G-quadruplexes is so far limited. Herein, we report a new
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Can we use it in fixed cells?
1 answer-
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