It would help prospective buyers if you included a list of research papers where this antibody has been used. For example:
Dart, A. E., Worth, D. C., Muir, G., Chandra, A., Morris, J. D., McKee, C., Verrill, C., Bryant, R. J. and Gordon-Weeks, P. R. (2017) The drebrin/EB3 pathway drives invasive activity in prostate cancer. Oncogene, 36, 4111-4123.
Trivedi, N., Stabley, D. R., Cain, B. et al. (2017) Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection. Nature Comms, 8, 14484.
Uddin, B., Partscht, P., Chen, N. P. et al. (2019) The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation. EMBO reports, 20(1):e46544.
Poobalasingham, T., Bianco, F., Oozeer, F. and Gordon-Weeks, P. R. (2022) The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. J. Neurochem., 160, 185-202.
Chen, C., Chu, C. H., Chu, Y. et al. (2022) Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment. Cell Reports, 40, 111188.
MABN833
Anti-phospho Drebrin (Ser142), clone 3C14 Antibody
Anti-phospho Drebrin (Ser142), clone 3C14 Antibody
1 of 1 reviewers received a sample product or took part in a promotion
clone 3C14, from mouse
Synonim(y):
Drebrin, Developmentally-regulated brain protein
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wybierz wielkość
100 μG
2030,00 zł
Wybierz wielkość
Zmień widok
100 μG
2030,00 zł
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
3C14, monoclonal
reaktywność gatunkowa
human, mouse, rat
metody
immunocytochemistry: suitable
inhibition assay: suitable (peptide)
western blot: suitable
izotyp
IgG3κ
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
phosphorylation (pSer142)
informacje o genach
human ... DBN1(1627)
Opis ogólny
Developmentally-regulated brain protein, also known as Drebrin, and encoded by the gene name DBN1, is a developmentally-regulated neuron-specific protein, expressed during outgrowth and maturation of dendrites, and localized within dendrites of the adult brain. Drebrin is required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. Recent studies have shown that Drebrins may play a role in cell migration, extension of neuronal processes and plasticity of dendrites. Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related. Adult rat brain expresses only drebrin A while drebrin E1 or E2 is observed in immature animals. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals have been observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of Drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of Drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast. Drebrin is expressed mainly in brain neurons.
Immunogen
KLH-conjugated linear peptide corresponding to rat phospho Drebrin (Ser142).
Zastosowanie
Anti-phospho Drebrin (Ser142), clone 3C14 | MABN833 is an antibody against phospho Drebrin for use in Western Blotting, Immunocytochemistry, Peptide Inhibition Assay.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected phospho Drebrin (Ser142) in 10 µg of rat neonatal brain tissue lysate.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected phospho Drebrin (Ser142) in HeLa and NIH/3T3 cells.
Peptide Inhibition Analysis: 0.5 µg/mL from a representative lot detected phospho Drebrin (Ser142) in 10 µg of rat neonatal brain tissue lysate.
Immunocytochemistry Analysis: A representative lot detected phospho Drebrin (Ser142) in rat embryonic cortical culture (Prof. Phillip R. Gordon-Weeks, King′s College London).
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected phospho Drebrin (Ser142) in HeLa and NIH/3T3 cells.
Peptide Inhibition Analysis: 0.5 µg/mL from a representative lot detected phospho Drebrin (Ser142) in 10 µg of rat neonatal brain tissue lysate.
Immunocytochemistry Analysis: A representative lot detected phospho Drebrin (Ser142) in rat embryonic cortical culture (Prof. Phillip R. Gordon-Weeks, King′s College London).
Jakość
Evaluated by Western Blotting in SH-SY5Y cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected phospho Drebrin (Ser142) in 10 µg of SH-SY5Y cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected phospho Drebrin (Ser142) in 10 µg of SH-SY5Y cell lysate.
Opis wartości docelowych
~100 kDa observed. The calculated molecular weight is 71 kDa, however phospho Drebrin (Ser142) has been shown as a ~100 kDa band in western blots (Worth, D.C., et al. (2013). JCB. 202(5):793-806).
Postać fizyczna
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Inne uwagi
Concentration: Please refer to lot specific datasheet.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Paloma Alvarez-Suarez et al.
International journal of molecular sciences, 22(17) (2021-09-11)
Proper muscle function depends on the neuromuscular junctions (NMJs), which mature postnatally to complex "pretzel-like" structures, allowing for effective synaptic transmission. Postsynaptic acetylcholine receptors (AChRs) at NMJs are anchored in the actin cytoskeleton and clustered by the scaffold protein rapsyn
Thanushiyan Poobalasingam et al.
Journal of neurochemistry, 160(2), 185-202 (2021-09-04)
Co-ordinating the dynamic behaviour of actin filaments (F-actin) and microtubules in filopodia is an important underlying process in neuritogenesis, but the molecular pathways involved are ill-defined. The drebrin/end-binding protein 3 (EB3) pathway is a candidate pathway for linking F-actin to
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