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ABE68

Sigma-Aldrich

Anti-FoxP1 Antibody

serum, from rabbit

Synonim(y):

forkhead box P1, fork head-related protein like B, glutamine-rich factor 1

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Wybierz wielkość

100 μL
1550,00 zł

1550,00 zł


Przewidywany termin wysyłki05 maja 2025Szczegóły


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100 μL
1550,00 zł

About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

1550,00 zł


Przewidywany termin wysyłki05 maja 2025Szczegóły


Poproś o zamówienie zbiorcze

pochodzenie biologiczne

rabbit

Poziom jakości

forma przeciwciała

serum

rodzaj przeciwciała

primary antibodies

klon

polyclonal

reaktywność gatunkowa

human, mouse

metody

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

izotyp

IgG

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... FOXP1(27086)

Opis ogólny

Forkhead Box P1 (FoxP1) is a member of the FOX family of transcription factors. This protein is known to forms homodimers and heterodimers with family members FoxP2 and FoxP4. The forkhead box family has a broad range of functions. These proteins play important roles in immune response, organ development and the development of cancer. The FoxP1 protein is widely expressed and contains both forkhead (winged-helix) and C2H2 zinc finger nucleic acid-binding motifs. At least four different isoforms that result from alternative splicing of the mRNA transcript have been reported.

Specyficzność

This antibody recognizes FoxP1.

Immunogen

Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse FoxP1.

Zastosowanie

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FoxP1 in HeLa and NIH/3T3 cells.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)
Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Developmental Signaling
Use Anti-FoxP1 Antibody (Rabbit Polyclonal Antibody) validated in ICC, WB, IHC to detect FoxP1 also known as forkhead box P1, fork head-related protein like B, glutamine-rich factor 1.

Jakość

Evaluated by Western Blot in RAW264.7 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP1 on 10 µg of RAW264.7 cell lysate.

Opis wartości docelowych

79 kDa observed. Alternative splicing can result in cell type dependent isoforms.

Postać fizyczna

Unpurified
Unpurified rabbit polyclonal serum with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Komentarz do analizy

Control
RAW264.7 cell lysate

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1


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Odwiedź Bibliotekę dokumentów

Wei Zhang et al.
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Adiponectin (AdipoQ), a hormone abundantly secreted by adipose tissues, has multiple beneficial functions, including insulin sensitization as well as lipid and glucose metabolism. It has been reported that bone controls energy metabolism through an endocrine-based mechanism. In this study, we
Shifeng Ling et al.
Stem cell research & therapy, 14(1), 188-188 (2023-07-29)
Mesenchymal stem cells (MSCs) are widely used in a variety of tissue regeneration and clinical trials due to their multiple differentiation potency. However, it remains challenging to maintain their replicative capability during in vitro passaging while preventing their premature cellular
Catherine Konopacki et al.
Nature immunology, 20(2), 232-242 (2019-01-16)
Regulatory T cells (Treg cells), whose differentiation and function are controlled by transcription factor Foxp3, express the closely related family member Foxp1. Here we explored Foxp1 function in Treg cells. We found that a large number of Foxp3-bound genomic sites
Pei Liu et al.
Nature communications, 10(1), 5070-5070 (2019-11-09)
β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and thermogenesis. Adipose-specific deletion of Foxp1 leads to an increase
Hanjun Li et al.
The Journal of clinical investigation, 127(4), 1241-1253 (2017-02-28)
A hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these cellular events are orchestrated in the aging progress is

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