AB3000
Anti-IP3 Receptor Type II Antibody
Chemicon®, from rabbit
Synonim(y):
Inositol 1,4,5-Trisphosphate Receptor
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
mouse, hamster, human, monkey, rat
producent / nazwa handlowa
Chemicon®
metody
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... ITPR2(3709)
Specyficzność
Rabbit anti-Type II Inositol 1,4,5-Trisphosphate Receptor (IP3R) is directed against a synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor. The antibody is reactive with Type II IP3R from rat, mouse, human, hamster, and monkey.
Immunogen
Synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor
Zastosowanie
Anti-IP3 Receptor Type II Antibody detects level of IP3 Receptor Type II & has been published & validated for use in IC, IF, IH, IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Western blot: 1:50 - 1:100 (detects a 260 kDa band)
Immunofluorescence: 1:10 - 1:20
Immunoprecipitation
Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines.
Immunohistochemistry: Paraformaldehyde or methanol fixes are effective.
Optimal working dilutions must be determined by end user.
Immunofluorescence: 1:10 - 1:20
Immunoprecipitation
Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines.
Immunohistochemistry: Paraformaldehyde or methanol fixes are effective.
Optimal working dilutions must be determined by end user.
Postać fizyczna
Affinity purified versus immobilized immunogen peptide. Liquid in PBS buffer, containing 0.05% BSA, 10% glycerol, 0.005% sodium azide. Caution: Sodium azide is hazardous. MSDS available upon request.
Przechowywanie i stabilność
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Robert P Brumer et al.
The Journal of physiology, 601(8), 1383-1405 (2023-03-04)
Excess consumption of carbohydrates, fat and calories leads to non-alcoholic fatty liver disease (NAFLD) and hepatic insulin resistance; these are major factors in the pathogenesis of type II diabetes. Hormones and catecholamines acting through G-protein coupled receptors (GPCRs) linked to
Mark Chalmers et al.
The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
Shafi Kuchay et al.
Nature, 546(7659), 554-558 (2017-06-15)
In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2+
Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.
Gerasimenko, JV; Lur, G; Sherwood, MW; Ebisui, E; Tepikin, AV; Mikoshiba, K; Gerasimenko et al.
Proceedings of the National Academy of Sciences of the USA null
Marta Gómez-Gonzalo et al.
Glia, 65(4), 569-580 (2017-01-29)
Astrocytes play crucial roles in brain homeostasis and are emerging as regulatory elements of neuronal and synaptic physiology by responding to neurotransmitters with Ca2+ elevations and releasing gliotransmitters that activate neuronal receptors. Aging involves neuronal and astrocytic alterations, being considered
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