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In the lyophilized form, this product is stored refrigerated at 2 - 8°C. This item is assigned a retest date, which is reported on the lot-specific Certificate of Analysis. Upon reconstitution at 20 mg/mL in DMSO, aliquot and store the solution at -20°C, protected from light, for up to 3 months.
616454
A 83-01
≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem
Synonim(y):
Inhibitor kinazy receptora transformującego czynnika wzrostu-β typu I IV, 3-(6-metylopirydyn-2-ylo)-4-(4-chinolilo)-1-fenylotiokarbamoilo-1H-pirazol, A-83-01, Inhibitor ALK5 IV
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2 MG
986,00 zł
10 MG
3970,00 zł
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Przewidywany termin wysyłki22 kwietnia 2025Szczegóły
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2 MG
986,00 zł
10 MG
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About This Item
Wzór empiryczny (zapis Hilla):
C25H19N5S
Numer CAS:
Masa cząsteczkowa:
421.52
Numer MDL:
Kod UNSPSC:
12352200
NACRES:
NA.54
986,00 zł
Przewidywany termin wysyłki22 kwietnia 2025Szczegóły
Polecane produkty
Nazwa produktu
TGF-β RI Kinase Inhibitor IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).
Poziom jakości
Próba
≥97% (HPLC)
Formularz
solid
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
protect from light
kolor
pale yellow
rozpuszczalność
DMSO: 20 mg/mL
Warunki transportu
ambient
temp. przechowywania
2-8°C
ciąg SMILES
S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1
InChI
1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
Klucz InChI
HIJMSZGHKQPPJS-UHFFFAOYSA-N
Opis ogólny
A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
Działania biochem./fizjol.
Cell permeable: yes
Primary Target
ALK-4/5/7
ALK-4/5/7
Product does not compete with ATP.
Reversible: no
Target IC50: 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Harmful (C)
Rekonstytucja
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Inne uwagi
Tojo, M., et al. 2005. Cancer Sci.96, 791.
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Certyfikaty analizy (CoA)
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