407331
ILK inhibitor, Cpd 22
The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonim(y):
ILK inhibitor, Cpd 22
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Wybierz wielkość
5 MG
890,00 zł
890,00 zł
Przewidywany termin wysyłki22 kwietnia 2025Szczegóły
Wybierz wielkość
Zmień widok
5 MG
890,00 zł
About This Item
Wzór empiryczny (zapis Hilla):
C30H30F3N5O
Masa cząsteczkowa:
533.59
Kod UNSPSC:
12352200
NACRES:
NA.77
890,00 zł
Przewidywany termin wysyłki22 kwietnia 2025Szczegóły
Polecane produkty
Poziom jakości
Próba
≥94% (HPLC)
Formularz
powder
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
protect from light
kolor
off-white
rozpuszczalność
DMSO: 100 mg/mL
Warunki transportu
ambient
temp. przechowywania
2-8°C
Opis ogólny
A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Standard Handling (A)
Rekonstytucja
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Inne uwagi
Lee, S., et al. 2011. J. Med. Chem.54, 6364
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Ta strona może zawierać tekst przetłumaczony maszynowo.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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