C2743

Cytochalasin B from Drechslera dematioidea

Ready Made Solution, 10 mg/mL in DMSO

• Synonim(y): Phomin
• Wzór empiryczny (zapis Hilla): C₂₉H₃₇NO₅
• Numer CAS: 14930-96-2
• Masa cząsteczkowa: 479.61
• Beilstein: 1096207
• Numer MDL: MFCD00077704
• Kod UNSPSC: 51102829
• Identyfikator substancji w PubChem: 329774749
• NACRES: NA.85

Właściwości

• Poziom jakości: 200
• Postać: solution
• stężenie: 10 mg/mL in DMSO
• spektrum działania antybiotyku: fungi
• Tryb działania: cell membrane | interferes
• temp. przechowywania: −20°C
• ciąg SMILES: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• Klucz InChI: GBOGMAARMMDZGR-TYHYBEHESA-N

Opis

Zastosowanie

Cytochalasin B from Drechslera dematioidea has been used:

• to block cytokinesis, to obtain binucleated cells
• as a specific glucose transporter inhibitor
• to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells

Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils , and to stimulate B lymphocytes .

Działania biochem./fizjol.

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H330
• Zwroty wskazujące środki ostrożności: P260 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P310
• Klasyfikacja zagrożeń: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 185.0 °F - closed cup - Solvent
• Temperatura zapłonu (°C): 85 °C - closed cup - Solvent
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter