178501
Palmostatin B
≥95% (HPLC), solid, APT1 inhibitor, Calbiochem®
Synonim(y):
Inhibitor APT1
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Wybierz wielkość
5 MG
1100,00 zł
1100,00 zł
Przewidywany termin wysyłki17 kwietnia 2025Szczegóły
Wybierz wielkość
Zmień widok
5 MG
1100,00 zł
About This Item
Wzór empiryczny (zapis Hilla):
C23H36O4
Masa cząsteczkowa:
376.53
Kod UNSPSC:
12352200
NACRES:
NA.77
1100,00 zł
Przewidywany termin wysyłki17 kwietnia 2025Szczegóły
Polecane produkty
Nazwa produktu
Inhibitor APT1, palmostatyna B, The APT1 Inhibitor, palmostatin B controls the biological activity of APT1.
Poziom jakości
Próba
≥95% (HPLC)
Formularz
solid
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
protect from light
kolor
off-white
rozpuszczalność
DMSO: 100 mg/mL
Warunki transportu
wet ice
temp. przechowywania
−20°C
Opis ogólny
A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC50 = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cβ and D. It′s inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA. Also available as a 50 mM solution in DMSO (Cat. No. 508738).
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Standard Handling (A)
Inne uwagi
Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett.19, 1376.
Dekker, F., et al. 2010. Nat. Chem. Biol.6, 449.
Dekker, F., et al. 2010. Nat. Chem. Biol.6, 449.
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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