860506P

C6 Ceramide (d18:1/6:0)

Avanti Research^™ - A Croda Brand

• Synonim(y): N-hexanoyl-D-erythro-sphingosine
• Wzór empiryczny (zapis Hilla): C₂₄H₄₇NO₃
• Numer CAS: 124753-97-5
• Masa cząsteczkowa: 397.63
• Kod UNSPSC: 12352211
• NACRES: NA.25

Właściwości

• Postać: powder
• opakowanie: pkg of 1 × 10 mg (860506P-10mg); pkg of 1 × 5 mg (860506P-5mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• typ lipidu: sphingolipids
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
• Klucz InChI: NPRJSFWNFTXXQC-VHEBQXMUSA-N

Opis

Opis ogólny

C6 Ceramide (d18:1/6:0) is a short chain and a cell permeable ceramide. It comprises amino alcoholic chain attached to fatty acyl chain via an amide linkage.

Zastosowanie

C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.

Działania biochem./fizjol.

C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.

Opakowanie

5 mL Amber Glass Screw Cap Vial (860506P-10mg)

5 mL Amber Glass Screw Cap Vial (860506P-5mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable