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Merck

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Synonimy:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

Numer produktu
Opis
Gatunek
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Gatunek
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Gatunek
rat

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
Capsazepine, ≥98% (HPLC), solid,
Gatunek
human, rat
Capsaicin, natural,
Gatunek
rat, human
Capsaicin, ≥95%, from Capsicum sp.,
Gatunek
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Gatunek
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Gatunek
human, rat, mouse

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
canine, human, mouse, rat
Zastosowanie
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Trpv4 Antibody, clone 1B2.6, clone 1B2.6, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunocytochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, rabbit
Zastosowanie
immunohistochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, rabbit
Zastosowanie
immunohistochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reaktywność gatunkowa
rat
Zastosowanie
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
Butamben, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Capsaicin, natural,
Gatunek
rat, human
Capsaicin, ≥95%, from Capsicum sp.,
Gatunek
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Gatunek
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Gatunek
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

Numer produktu
Opis
Gatunek
N-Vanillylnonanamide, ≥97%, powder,
Gatunek
rat
Capsazepine, ≥98% (HPLC), solid,
Gatunek
human, rat

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Trpv4,
Gatunek
mouse
MISSION® esiRNA, targeting human TRPV4,
Gatunek
human