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HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Synonimy:
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(3091) Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
  • Mouse(15251) hypoxia inducible factor 1, alpha subunit
  • Rat(29560) hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • dog(480348) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • domestic guinea pig(100713113) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • naked mole-rat(101715845) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • Domestic Rabbit(100009579) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • sheep(443519) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • cow(281814) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • domestic cat(101083686) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • chicken(374177) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Custom & Knockdown Gene Products

ELISA

Numer produktu
Opis
Gatunek
Ludzki zestaw HIF-1 alfa ELISA, for cell culture supernatants, plasma, and serum samples,
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-HIF-1 alpha antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM242, purified immunoglobulin,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
Anty-HIF1A, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-HIF1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Anti-HIF1A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot
Przeciwciało anty-HIF1Aprodukowane u królików, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot

Cell Lines

Numer produktu
Opis
Gatunek
A549 Cells HIF1A -/-/-, ,
Gatunek
human
DLD1 Cells HIF1A -/-, ,
Gatunek
human
SW48 Cells HIF1A -/-/-, ,
Gatunek
human

Proteins

Numer produktu
Opis
Gatunek
HIF-1 α, C-terminal activation domain (776-826 human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Gatunek
human
HIF-1 α N-terminal activation domain (530-698) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human HIF1A,
Gatunek
human
MISSION® esiRNA, targeting mouse Hif1a,
Gatunek
mouse