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ACHE

acetylcholinesterase

Synonimy:
ACEE, ARACHE, N-ACHE, YT
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

Numer produktu
Opis
Gatunek
(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;chloride, United States Pharmacopeia (USP) Reference Standard,
Gatunek
human
Pyridine-2-aldoxime methochloride, ,
Gatunek
human

Small Molecule - Agonist

Numer produktu
Opis
Gatunek
Acetylthiocholine chloride, ≥99% (TLC), powder,
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-ACHE, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Zastosowanie
immunofluorescence
immunohistochemistry

western blot
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
cat, human, mouse, rabbit, rat
Zastosowanie
ELISA
flow cytometry

immunofluorescence

western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
Reaktywność gatunkowa
bovine, canine, chicken, guinea pig, human, monkey
Zastosowanie
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, rat
Zastosowanie
western blot
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
Donepezil hydrochloride, ≥98% (HPLC),
Gatunek
human
Pyridostigmine bromide, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Neostigmine methyl sulfate, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Pyridostigmine bromide, ,
Gatunek
human
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate, ≥99%,
Gatunek
human

Kits

Numer produktu
Opis
Gatunek
Acetylcholinesterase Activity Assay Kit, sufficient for 100 colorimetric tests,
Gatunek
mouse, human

Proteins

Numer produktu
Opis
Gatunek
Acetylcholinesterase human, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
Gatunek
human
Acetylcholinesterase from human erythrocytes, buffered aqueous solution, ≥500 units/mg protein (BCA),
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human ACHE,
Gatunek
human