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Merck
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主要文件

SML0860

Sigma-Aldrich

阿比朵尔 盐酸盐

≥98% (HPLC)

别名:

6-溴-4-((二甲氨基)甲基)-5-羟基-1-甲基-2-((苯硫基)甲基)-1H-吲哚-3-羧酸乙酯 单盐酸盐

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About This Item

经验公式（希尔记法）:
C22H25BrN2O3S · HCl
CAS号:
131707-23-8
分子量:
513.88
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C22H25BrN2O3S.ClH.H2O/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;;/h6-11,26H,5,12-13H2,1-4H3;1H;1H2

InChI 密鑰

PLWQHPWNKPKQJT-UHFFFAOYSA-N

生化／生理作用

盐酸阿比多尔（ARB）是一种小分子单眼用化合物。用于预防流感病毒（IFV）诱导的重症肺炎和病毒相关细胞因子失调。ARB还具有一些免疫调节特性，包括干扰素诱导和巨噬细胞活化的作用。
阿比多尔是一种广谱抗病毒药，已证明对多种包膜和非包膜病毒具有活性，并在临床上用于治疗流感。阿比多尔抑制病毒进入宿主细胞并刺激免疫反应。阿比多尔抑制病毒衣壳与靶细胞的细胞膜之间的融合，从而防止病毒进入。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Xin Xiong et al.
Journal of AOAC International, 94(4), 1100-1105 (2011-09-17)
An HPLC/MS/MS method for the determination of arbidol in human plasma was developed. Arbidol and internal standard (loratadine) were extracted from alkaline plasma with tert-butyl methyl ether and analyzed on a Zorbax SB C18 column (30 x 2.1 mm id
S Ia Loginova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 55(1-2), 6-11 (2010-06-30)
Efficacy of arbidol and ridostin in cupping postvaccinal complications due to variolation was studied by the clinico-virological, hematological and biochemical indices and it was shown that arbidol was efficient in cupping development of dermal complications, lowered the severity of the
Meng Wang et al.
Drug and chemical toxicology, 33(3), 244-253 (2010-05-01)
The antiviral drug combination consisting of arbidol and acetaminophen was investigated for its 4-week repeated oral administration in Sprague-Dawley rats. Groups of rats (10/sex in low-dose group, 15/sex in other three groups) were given at doses of 0, 200, 400
Elodie Teissier et al.
PloS one, 6(1), e15874-e15874 (2011-02-02)
The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane. To better understand Arb mechanism of action, we investigated its interactions with phospholipids and membrane peptides. We demonstrate that Arb associates
N K Chernikova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 56(9-10), 19-22 (2011-01-01)
The experiments on guinea pigs showed that arbidol administered orally in a single dose 24 hours prior vaccination with TEOVAC and ridostin administered in a single dose intranasally on the 4th day after the vaccination lowered the vaccine virus accumulation
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