G7048

氯胍 盐酸盐

≥95% (HPLC)

• 别名: Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• 经验公式（希尔记法）: C₁₁H₁₆ClN₅·HCl
• CAS号: 637-32-1
• 分子量: 290.19
• EC 号: 211-283-7
• MDL编号: MFCD01732193
• UNSPSC代码: 51101906
• PubChem化学物质编号: 329799959
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: solid
• 储存条件: desiccated
• 溶解性: acetonitrile: water: ~1 mg/mL (60/40)
• 创始人: AstraZeneca
• 储存温度: 2-8°C
• SMILES字符串: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI key: SARMGXPVOFNNNG-UHFFFAOYSA-N

说明

应用

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

生化/生理作用

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301
• 预防措施声明: P264 - P270 - P301 + P310 - P405 - P501
• 危险分类: Acute Tox. 3 Oral
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable