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Merck
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文件

SML0564

Sigma-Aldrich

PD153035 盐酸盐

≥98% (HPLC)

别名:

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868

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About This Item

经验公式（希尔记法）:
C16H14BrN3O2 · HCl
CAS号:
183322-45-4
分子量:
396.67
MDL號碼:
MFCD01074805
分類程式碼代碼:
51111800
PubChem物質ID:
329825555
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

Cl.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

InChI

1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

InChI 密鑰

ZJOKWAWPAPMNIM-UHFFFAOYSA-N

生化／生理作用

PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Skull and crossbonesCorrosion
GHS06,GHS05

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Rainelli B Koumangoye et al.
Molecular cancer, 12(1), 167-167 (2013-12-21)
The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-surface receptors to promote cellular processes
Amelia G Pérez et al.
Oncology reports, 44(4), 1649-1661 (2020-09-19)
Changes in protein levels in different components of the apical junctional complex occur in colorectal cancer (CRC). Claudin‑3 is one of the main constituents of tight junctions, and its overexpression can increase the paracellular flux of macromolecules, as well as
Naoya Hino et al.
Developmental cell, 53(6), 646-660 (2020-06-05)
During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission
Benjamin Toh et al.
PLoS biology, 9(9), e1001162-e1001162 (2011-10-08)
In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of selected, random mutations and thus would occur late in cancer progression. However, recent studies show
Carlos Pardo-Pastor et al.
Science advances, 9(39), eadi1328-eadi1328 (2023-09-27)
EGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. While EGF ligand and mechanical inputs can activate EGFR-ERK signaling, the molecules linking mechanical force to this axis have remained mysterious. We previously found that stretch promotes mitosis via
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