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Merck
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SML0320

Sigma-Aldrich

FR180204

≥98% (HPLC)

别名:

5-(2-苯基-吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]哒嗪-3-基胺, 5-(2-苯基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]吡啶并-3-胺, FR 180204

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About This Item

经验公式（希尔记法）:
C18H13N7
CAS号:
865362-74-9
分子量:
327.34
MDL编号:
MFCD14585805
UNSPSC代码:
12352200
PubChem化学物质编号:
329825325
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

faintly yellow to dark yellow

溶解性

DMSO: ≥10 mg/mL

储存温度

2-8°C

SMILES字符串

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

InChI key

XVECMUKVOMUNLE-UHFFFAOYSA-N

应用

FR180204已被用作ERK抑制剂：
  • 用于阻断细胞外信号调节激酶 (ERK) 以确认同源框B7 (HOXB7) 是否通过 AKT/丝裂原活化蛋白激酶 (MAPK) 信号传导调节迁移和增生过程
  • 作为细胞外信号调节激酶 (ERK) 抑制剂用于研究信号通路抑制剂对分化和细胞牵引力的作用
  • 用于确定这种信号蛋白对于间充质基质细胞(MSC)治疗功效是不是必需的。

生化/生理作用

FR180204是一种有效的、选择性的、细胞可渗透的、具有ATP竞争性的ERK1和ERK2抑制剂。
FR180204是一种有效的细胞渗透性、ATP竞争性ERK1和ERK2抑制剂（促分裂原活化蛋白激酶（MAPK）/细胞外信号调节激酶（ERK）1/2）。
它可用于研究ERK的作用并用于药物开发。

特点和优势

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面，请点击此处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000391910
0000391911
0000302342
0000302342
0000391911

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HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
He X, et al.
Oncotarget, 8(1), 1247-1247 (2017)
Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells
Kourouklis AP, et al.
Biomaterials, 99, 82-94 (2016)
The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia
Gupta N, et al.
Stem Cells, 36(5), 796-806 (2018)
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Ohori M, et al.
Biochemical and biophysical research communications, 336(1), 357-363 (2005)
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
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