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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 60 kDa
物種活性
rat, human, mouse
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr530)
基因資訊
human ... FYN(2534)
一般說明
Tyrosine-protein kinase FYN is a neuronally enriched cytoplasmic protein. It is encoded by the genes mapped to human chromosome 6q21. FYN protein belongs to the proto-oncogene tyrosine-protein kinase, Src family.
免疫原
The antiserum was produced against synthesized peptide derived from human Fyn around the phosphorylation site of Tyr530.
Immunogen Range: 488-537
Immunogen Range: 488-537
應用
Anti-phospho-Fyn (pTyr530) antibody produced in rabbit has been used in immunoprecipitation and immunoblotting.
生化／生理作用
Tyrosine-protein kinase FYN and phospho-FYN act as signaling systems for spatial memory. Phospho-FYN plays a vital role in the regulation of oligodendrocyte myelination and neurofilament phosphorylation. FYN aids in the development and activation of T cells in various physiological conditions. Overexpression of the FYN gene has been observed in various types of cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Matthias Schmitz et al.
Molecular neurobiology, 50(3), 923-936 (2014-03-08)
The cellular prion protein (PrPC) is a highly conserved protein whose exact physiological role remains elusive. In the present study, we investigated age-dependent behavioral abnormalities in PrPC-knockout (Prnp0/0) mice and wild-type (WT) controls. Prnp0/0 mice showed age-dependent behavioral deficits in
Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases.
Zhao, et al.
Cancer research, 73, 6149-6163 (2018)
Feng Xue et al.
Surgical oncology, 33, 108-117 (2020-06-21)
Tyrosine-protein kinase Fyn (FYN) plays a crucial role in Src family, which participates in the signal transduction of brain nerves and the development and activation of T lymphocytes in physiological conditions. We probed into the roles and mechanisms of FYN
Yuta Shimanaka et al.
Nature medicine, 23(11), 1287-1297 (2017-10-17)
Critical to the function of mast cells in immune responses including allergy is their production of lipid mediators, among which only omega-6 (ω-6) arachidonate-derived eicosanoids have been well characterized. Here, by employing comprehensive lipidomics, we identify omega-3 (ω-3) fatty acid
Haley Peckham et al.
Glia, 64(2), 255-269 (2015-10-10)
Fyn, a member of the Src family of nonreceptor tyrosine kinases, promotes central nervous system myelination during development; however the mechanisms mediating this effect remain unknown. Here we show that Fyn phosphorylation is modulated by BDNF in vivo. Concordant with
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