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生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
10.1.5, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~125 kDa
物種活性
bovine, human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 2.5-5.0 μg/mL using MCF7 cells.
western blot: 2.0-4.0 μg/mL using TF1 total cell extracts.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... JAK2(3717)
一般說明
Monoclonal Anti-JAK2 (mouse IgG1 isotype) is derived from the hybridoma 10.1.5 produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. The Janus kinases (Jak) family of proteins includes four members: Jak1, Jak2, Jak3 and the tyrosine kinase 2 (Tyk2). Jak2 is ubiquitously expressed. It is also expressed in normal and neoplastic mammary epithelial cells.
免疫原
synthetic peptide corresponding to an internal sequence of human JAK2 (GeneID 3717), conjugated to KLH.
應用
Monoclonal Anti-JAK2 antibody produced in mouse has been used in:
- immunoblotting
- immunocytochemistry
- flow cytometry
生化／生理作用
Janus kinases engage in interactions with the intracellular tails of several cytokine receptors, which result in the activation of members of the signal transducer and activator of transcription (STAT) family of transcription factors. The latter bind specific cognate sequences at the promoter region of genes that regulate proliferation and differentiation. JAK activation plays an important role in cell proliferation, differentiation, migration and apoptosis. A member of this family, JAK2, has been found to induce signaling regulating gene expression of various pro-survival and anti-apoptotic molecules. Furthermore, inhibition of JAK2 signaling triggered cell death in human cancer cells. These findings indicate JAK2 inhibition as a potential therapeutic approach for various cancers.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Spleen deflation and beyond: The pros and cons of Janus kinase 2 inhibitor therapy for patients with myeloproliferative neoplasms
Quintas CA and Verstovsek S
Cancer, 118(4), 870-877 (2012)
Reetobrata Basu et al.
Oncotarget, 8(13), 21579-21598 (2017-02-23)
Recent reports have confirmed highest levels of growth hormone (GH) receptor (GHR) transcripts in melanoma, one of the most aggressive forms of human cancer. Yet the mechanism of GH action in melanoma remains mostly unknown. Here, using human malignant melanoma
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
Li F, et al.
British Journal of Pharmacology, 161(3), 541-554 (2010)
Janus kinases in immune cell signaling
Ghoreschi K, et al.
Immunological Reviews, 228(1), 273-287 (2009)
The two faces of Janus kinases and their respective STATs in mammary gland development and cancer
Wagner KU and Schmidt JW
Journal of Carcinogenesis, 10, 273-287 (2011)
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