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L0517

Sigma-Aldrich

白三烯B4

~100 μg/mL in ethanol, ≥97%

别名:

[5S，12R]-二羟基-[6Z，8E，10E，14Z]-二十碳四烯酸

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About This Item

经验公式（希尔记法）:
C20H32O4
CAS号:
71160-24-2
分子量:
336.47
EC號碼:
200-578-6
MDL號碼:
MFCD00135630
分類程式碼代碼:
12352200
PubChem物質ID:
24896256
NACRES:
NA.77

品質等級

200

化驗

≥97%

形狀

liquid

濃度

~100 μg/mL in ethanol

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

InChI

1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1

InChI 密鑰

VNYSSYRCGWBHLG-AMOLWHMGSA-N

基因資訊

human ... LTB4R(1241)
rat ... Ltb4r(59264)

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生化／生理作用

促炎剂。刺激人单核细胞中c-Fos和c-Jun原癌基因的转录。刺激多形核白细胞的趋化性、聚集和脱粒。

特點和優勢

《受体分类和信号转导》手册的白三烯受体和核受体页面重点介绍了该化合物。想要浏览手册的其他页面， 请单击此处。

包裝

每种产品附带的数据表包含特殊处理说明。除非另有说明，否则还对甲酯水解的方法进行了描述。

象形圖

FlameExclamation mark
GHS02,GHS07

訊號詞

Danger

危險聲明

H225,H319

危險分類

Eye Irrit. 2 - Flam. Liq. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

57.2 °F - closed cup

閃點（°C）

14.0 °C - closed cup

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Nicolas Cenac et al.
Gastroenterology, 149(2), 433-444 (2015-04-26)
In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA)
Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis.
Jesper Z Haeggström
The Journal of biological chemistry, 279(49), 50639-50642 (2004-09-02)
H E Claesson et al.
International journal of immunopharmacology, 14(3), 441-449 (1992-04-01)
Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to
Vincenzo Quagliariello et al.
Journal of personalized medicine, 10(4) (2020-10-23)
Several strategies based on immune checkpoint inhibitors (ICIs) have been developed for cancer therapy, opening to advantages in cancer outcomes. However, several ICI-induced side effects have emerged in these patients, especially a rare but clinically significant cardiotoxicity with high rate
Lloyd Tanner et al.
Journal of innate immunity, 12(3), 203-225 (2019-09-19)
Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide.
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