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Key Documents

HPA003733

Sigma-Aldrich

抗-THY1 兔抗

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-CD90抗原, 抗-Thy-1膜糖蛋白前体, 抗CDw90, 抗Thy-1抗原

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

加強驗證

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

免疫原序列

VTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWL

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... THY1(7070)

一般說明

Thy-1细胞表面抗原(Thy-1)/CD90(分化簇90)是25-37kDa的糖磷脂酰肌醇(GPI)锚定糖蛋白。在小鼠T细胞中首先发现。Thy-1表达于胸腺细胞、T细胞、神经元、造血干细胞、癌症干细胞、内皮细胞和成纤维细胞。该基因位于人染色体11q23。
Thy-1(Thy-1细胞表面抗原)是属于免疫球蛋白超基因家族的18,000Da的糖蛋白。在羧基端含有疏水片段,并有一个N-糖基化位点。

免疫原

Thy-1膜糖蛋白前体重组蛋白抗原表位标签(PrEST)

應用

由Atlas Antibodies提供技术支持的所有Prestige Antibodies抗体均由人类蛋白质图集(HPA)项目开发和验证,因此受到业内最广泛的表征支持。

人类蛋白质图集项目可以分为三大部分: 人体组织图谱、癌症图谱和人类细胞图谱。在组织和癌症图谱项目支持下产生的抗体已通过对数百种正常和疾病组织的免疫组织化学分析得到了验证,并且通过近期人类细胞图谱项目的努力,许多抗体已经过免疫荧光分析的表征,从而绘制人类蛋白质组图谱,不仅是在组织水平上,现在已经达到亚细胞水平。在人类蛋白质图集项目网站上单击图像库链接,可以查看这些图像和庞大的数据集。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。

生化/生理作用

Thy-1又名CD90(分化簇90)。该基因参与侵袭,与上皮间质转化有关。是诊断上皮样间皮瘤的新型标志物。可作为有希望的男性乳腺癌新型预后标志物。它可作为多种肿瘤及癌症干细胞的生物标志物,也可能参与肝细胞癌(HCC)的发生发展。它还可作为肺癌干细胞的潜在标志物。
Thy-1细胞表面抗原(Thy-1)/CD90(分化簇90)参与T细胞活化、神经突生长调节、突触神经递质的囊泡释放、星形胶质细胞粘附、癌细胞凋亡、肿瘤抑制、伤口愈合、纤维化和纤维生成。还调控成纤维细胞粘着斑、细胞骨架组织和细胞迁移。

特點和優勢

Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。

每种Prestige 抗体的检测方法如下:
  • 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
  • 364个人重组蛋白片段的蛋白阵列。

聯結

对应抗原APREST77497

外觀

磷酸盐缓冲盐水溶液,pH 7.2,含有40%甘油和0.02%叠氮化钠

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Xiuping Yan et al.
Oncology reports, 30(6), 2733-2740 (2013-10-09)
Accumulating evidence supports that cancer stem cells (CSCs) are responsible for tumor initiation, progression, distal metastasis and even drug resistance. Although CD90 has been identified as a marker for several types of stem cells, such as liver CSCs, the potential
T Seki et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(19), 6657-6661 (1985-10-01)
The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane
Caecilia Hapsari Ceriapuri Sukowati et al.
PloS one, 8(10), e76830-e76830 (2013-10-12)
Although the CD90 (Thy-1) was proposed as biomarker of several tumors and cancer stem cells, the involvement of this molecule in the progression of hepatocellular carcinoma (HCC) and other less frequent hepatic neoplasms is still undefined. The distribution of CD90
Kiyoko Kawamura et al.
American journal of clinical pathology, 140(4), 544-549 (2013-09-21)
To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma. We conducted immunohistochemical analyses on clinical specimens, including 26 cases of mesothelioma, 28 cases of lung adenocarcinoma, and 33 cases of lung squamous cell carcinoma. We found that CD90 expression was
Ida Johansson et al.
PloS one, 8(10), e78299-e78299 (2013-11-07)
The rapidly growing collection of diverse genome-scale data from multiple tumor types sheds light on various aspects of the underlying tumor biology. With the objective to identify genes of importance for breast tumorigenesis in men and to enable comparisons with

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