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H8891

Sigma-Aldrich

肝素酶III 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)

别名:

肝素裂解酶III, 肝素酶 来源于肝素黄杆菌, 肝素酶I

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About This Item

CAS号:
37290-86-1
EC 号:
4.2.2.8 (BRENDA, IUBMB)
MDL编号:
MFCD00131319
UNSPSC代码:
12352204
NACRES:
NA.54

生物来源

bacterial (Flavobacterium heparinum)

质量水平

200

偶联物

conjugate (Glucosaminoglycan)

表单

lyophilized powder

比活

≥30 units/mg protein (enzyme + BSA)

分子量

70.8 kDa

应用

diagnostic assay manufacturing

储存温度

−20°C

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应用

肝素黄杆菌肝素酶III已用于裂解特定GAG。已用于研究其对与抗aFGF（酸性成纤维细胞生长因子）抗体反应的蛋白质的电泳迁移率的影响。

生化/生理作用

肝素酶III可防止体内新血管的形成。它在HNY-I和HNY、6X-G2连接处特异性降解硫酸肝素。与其他肝素酶不同，肝素酶III不含氨基酸半胱氨酸。它含有13个组氨酸残基，这是其催化作用的原因。该酶对肝素或低分子量肝素没有活性。
肝素降解裂解酶，识别硫酸肝素蛋白聚糖为其主要底物。

单位定义

在25 °C、pH 7.5条件下，一个单位每小时可形成0.1 μM不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。包装规格基于Sigma单位。

其他说明

更多关于复杂碳水化合物分析酶的信息请见www.sigma-aldrich.com/enzymeexplorer

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H334

预防措施声明

P261 - P284 - P501

危险分类

Resp. Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000330444
0000369562
0000351404
0000310498
0000369562

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Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
Toh YC and Voldman J
Faseb Journal, 25(4), 1208-1217 (2011)
FGF binding by extracellular matrix components of Wharton's jelly
Malkowski A, et al.
Acta Biochimica Polonica, 54(2), 357-357 (2007)
Erin M Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(51), 21683-21688 (2009-12-08)
Platelet-derived growth factor (PDGF) signaling is essential for processes involving cell motility and differentiation during embryonic development in a wide variety of organisms including the mouse, frog, zebrafish, and sea urchin. In early Xenopus laevis embryos, PDGF-AA provides guidance cues
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