The solubility of this item is 1mg/ml as mentioned on the COA.
Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdf
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产品名称
硫酸乙酰肝素 钠盐 来源于牛肾,
储存温度
2-8°C
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生化/生理作用
硫酸乙酰肝素（HS）是一种普遍存在的糖胺聚糖，是D-葡萄糖醛酸或L-艾杜糖醛酸与D-葡萄糖胺（GlcA）糖的聚合物。[4]它是在顺式高尔基体中以肝素形式合成的。在高尔基体中，最终的硫酸乙酰肝素是通过N-和O-HS-硫转移酶以及HS差向异构酶的作用而合成的。成熟的HS具有50至200个二糖单元。[5]它是细胞外基质（ECM）的一部分并在致癌途径中起关键作用。硫酸肝素代谢的失调与癌症的进展有关。[6]HS与感染性疾病和炎性疾病的发作有关。[7]HS与Aβ淀粉样纤维作用，与阿兹海默症′有关。[8]硫酸乙酰肝素是膜结合蛋白聚糖的组成成分，具有细胞黏附作用。
膜相关蛋白聚糖的组成被认为有助于细胞间的粘附
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Molecular diversity of heparan sulfate
Esko JD and Lindahl Ulf
The Journal of Clinical Investigation, 108(2), 169-173 (2001)
K Fuxe et al.
Brain research, 746(1-2), 25-33 (1997-01-23)
In the present paper immunocytochemical analysis at the fluorescence microscopical level has been performed of neural cell adhesion. molecule (NCAM) immunoreactivity in the adult rat tel- and diencephalon in order to further substantiate the highly selective neuronal localization of NCAM
Pathophysiology of heparan sulphate: many diseases, few drugs
Lindahl Ulf and Kjellen L
Journal of Internal Medicine, 273(6), 555-571 (2013)
Fell-Muir lecture: heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra
Gallagher J
International Journal of Experimental Pathology, 96(4), 203-231 (2015)
Mechanism of fibronectin binding to human trabecular meshwork exosomes and its modulation by dexamethasone
Dismuke WM, et al.
Testing, 11(10), e0165326-e0165326 (2016)
商品
有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.
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