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H2519

Sigma-Aldrich

肝素酶 I 来源于肝素黄杆菌

Lyophilized powder stabilized with approx. 25% bovine serum albumin, ≥200 units/mg protein (enzyme + BSA)

别名:

肝素裂解酶I, 肝素酶

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About This Item

CAS号:
9025-39-2
EC 号:
4.2.2.7 (BRENDA, IUBMB)
MDL编号:
MFCD00131317
UNSPSC代码:
12352204
NACRES:
NA.54

偶联物

conjugate (Glucosaminoglycan)

质量水平

200

表单

lyophilized solid

比活

≥200 units/mg protein (enzyme + BSA)

分子量

42.8 kDa

应用

diagnostic assay manufacturing

储存温度

−20°C

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相关类别

应用

来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I已被用于：
  • 消化血浆样品
  • 研究培养基、洗涤和超声处理对肺炎衣原体(Chlamydia pneumonia)感染性的影响
  • 酶法去除人横纹肌肉瘤细胞表面的硫酸乙酰肝素

生化/生理作用

来自肝素黄杆菌（Flavobacterium heparinum）的肝素酶I通过裂解肝素AT III结合位点处的α-糖苷键而发挥作用。这就产生了小的寡糖碎片。肝素酶 I 可以中和蛋白质的抗凝作用。肝素酶I的半衰期为15-18分钟。

单位定义

在25 °C、pH 7.5条件下，一个单位（Sigma单位）每小时可形成0.1 μ摩尔不饱和糖醛酸。一个国际单位（I.U.）相当于大约600个Sigma单位。

其他说明

有关复合碳水化合物分析酶的更多信息，请见www.sigma-aldrich.com/enzymeexplorer

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H334

预防措施声明

P261 - P284 - P501

危险分类

Resp. Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000415193
0000415193
0000412860
0000412860
0000377328

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Coxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptor
Zhang X, et al.
Emerging microbes & infections, 6(7), e65-e65 (2017)
Udayanath Aich et al.
Analytical chemistry, 83(20), 7815-7822 (2011-08-26)
Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse
Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro
Yan Y, et al.
Journal of Microbiological Methods, 61(1), 127-130 (2005)
Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum
Murphy MSQ, et al.
American Journal of Obstetrics and Gynecology, 213(3), 367-e1-367-e1 (2015)
Cardiopulmonary Bypass: Principles and Practice, 509-509 (2008)
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