H5752

17α-羟基孕酮

≥95%

• 别名: 17α-羟基孕甾-4-烯-3,20-二酮, 17α-羟基黄体酮
• 经验公式（希尔记法）: C₂₁H₃₀O₃
• CAS号: 68-96-2
• 分子量: 330.46
• Beilstein: 3218109
• EC 号: 200-699-4
• MDL编号: MFCD00003659
• UNSPSC代码: 51111800
• PubChem化学物质编号: 24278469
• NACRES: NA.77

属性

• 生物来源: synthetic (organic)
• 质量水平: 200
• 无菌性: non-sterile
• 方案: ≥95%
• 表单: powder
• 溶解性: chloroform: 50 mg/mL, clear, colorless to light yellow
• 运输: ambient
• 储存温度: room temp
• SMILES字符串: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O
• InChI: 1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
• InChI key: DBPWSSGDRRHUNT-CEGNMAFCSA-N
• 基因信息: human ... PGR(5241) , SERPINA6(866) ; rat ... Ar(24208)

说明

一般描述

17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase.[1] 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.[2]

应用

17α-Hydroxyprogesterone has been used:

• for titration against ovarian S9 protein in thin-layer chromatography[3]
• as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures[4]
• as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)[5]

生化/生理作用

17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP.[6] High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).[6]

安全信息

• 象形图: GHS08,GHS09
• 警示用语：: Danger
• 危险声明: H360FD,H411
• 预防措施声明: P202 - P273 - P280 - P308 + P313 - P391 - P405
• 危险分类: Aquatic Chronic 2 - Repr. 1B
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 个人防护装备: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges