H-105

17α-羟孕烯醇酮 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 经验公式（希尔记法）: C₂₁H₃₂O₃
• CAS号: 387-79-1
• 分子量: 332.48
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: certified reference material
• 形狀: liquid
• 特點: (Snap-N-Spike^®)
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing; clinical testing
• 格式: single component solution
• 儲存溫度: −20°C
• InChI: 1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1
• InChI 密鑰: JERGUCIJOXJXHF-TVWVXWENSA-N

说明

一般說明

17α-羟基孕烯醇酮是在肾上腺中产生的类固醇激素。该激素是作为先天性肾上腺增生（CAH）的一种辅助检测而受到监测的，特别是在已经对21-羟化酶和11-羟化酶缺乏的诊断已被排除的情况下。该认证的加标溶液^®适合用作内分泌学、临床化学和新生儿筛查中大量LC-MS/MS应用的线性标准品、校准品和对照品的起始材料。

應用

• Enhancement of Steroidogenic Enzyme Assays: The role of protein-protein and protein-membrane interactions in cytochrome P450 function, which is crucial for understanding the enzymatic activities involved in steroid biosynthesis, including those mediated by 17 alpha-Hydroxypregnenolone (Scott EE et al., 2016).


• Modeling Steroid Hormone Biosynthesis: Research explores how ligand and cytochrome b5 modulate the conformation of human cytochrome P450 17A1, a key enzyme in the biosynthesis of neurosteroids from precursors like 17 alpha-Hydroxypregnenolone, providing insights for biochemical steroidogenesis research (Estrada DF et al., 2014).


• Development of ELISA for Steroid Detection: The study demonstrate the covalent coupling of steroids to microwell plates, facilitating the use of 17 alpha-Hydroxypregnenolone in competitive enzyme-linked immunosorbent assays (ELISA) for steroid hormone precursor detection and quantification in biochemical assays (Yonezawa S et al., 1993).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup