跳转至内容
Merck
所有图片(2)

主要文件

查看所有文档

G9518

Sigma-Aldrich

吉非罗齐

别名:

2,2-二甲基-5-(2,5-二甲基苯氧基)戊酸, 2,2-二甲基-5-(2,5-二甲苯氧基)戊酸, 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酸

登录查看公司和协议定价
所有图片(2)

About This Item

经验公式（希尔记法）:
C15H22O3
CAS号:
25812-30-0
分子量:
250.33
EC 号:
247-280-2
MDL编号:
MFCD00079335
UNSPSC代码:
12352200
PubChem化学物质编号:
24895377
NACRES:
NA.77

表单

powder

质量水平

100

SMILES字符串

Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI key

HEMJJKBWTPKOJG-UHFFFAOYSA-N

基因信息

human ... PPARA(5465)

正在寻找类似产品? 访问 产品对比指南

一般描述

吉非罗齐是一种纤维酸衍生物和降血脂药。吉非罗齐可作为 PPARα（过氧化物酶体增殖物激活受体 α）的配体。

应用

吉非罗齐已被用于研究其对酵母细胞周期进程的影响。它已被用于研究贝特类药物对人细胞系中细胞增殖和基因表达的影响。

生化/生理作用

吉非罗齐选择性增加载脂蛋白 A-I 水平。在酵母细胞中，吉非罗齐的应用会延迟 DNA 复制的开始。它被用作血脂异常的治疗药物。

特点和优势

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG9003
BCBP4924
BCBP4924V
030M1424V
SLBD3802V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Katerina Cizkova et al.
Lipids in health and disease, 15(1), 164-164 (2016-09-24)
Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered as potential anticancer agents. We studied effect of fibrates treatment on cell proliferation, expression of CYP2J2 and concomitant
Izabela Zakrocka et al.
Life (Basel, Switzerland), 13(11) (2023-11-25)
Kidney dysfunction significantly increases the cardiovascular risk, even in cases of minor functional declines. Hypertriglyceridemia is the most common lipid abnormality reported in patients with kidney disorders. PPAR-α (peroxisome proliferator-activated receptor-α) agonists called fibrates are the main agents used to
Benjamin Allcock et al.
Cells, 12(19) (2023-10-13)
It is widely recognised that cells respond to their microenvironment, which has implications for cell culture practices. Growth cues provided by 2D cell culture substrates are far removed from native 3D tissue structure in vivo. Geometry is one of many
A M Filppula et al.
Clinical pharmacology and therapeutics, 94(3), 383-393 (2013-05-10)
Cytochrome P450 (CYP) 3A4 is considered the most important enzyme in imatinib biotransformation. In a randomized, crossover study, 10 healthy subjects were administered gemfibrozil 600 mg or placebo twice daily for 6 days, and imatinib 200 mg on day 3, to study
Manthena V S Varma et al.
Pharmaceutical research, 29(10), 2860-2873 (2012-05-29)
To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport parameters. In vitro hepatic sinusoidal active uptake, passive diffusion and canalicular efflux intrinsic clearance values were determined using
查看所有相关文献

商品

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门