C4024

卡马西平

≥98% (HPLC), powder, sodium channel inhibitor

• 别名: 5H-二苯并[b,f]氮杂-5-甲酰胺
• 经验公式（希尔记法）: C₁₅H₁₂N₂O
• CAS号: 298-46-4
• 分子量: 236.27
• EC 号: 206-062-7
• MDL编号: MFCD00005073
• UNSPSC代码: 12352200
• eCl@ss: 34051404
• PubChem化学物质编号: 57654002
• NACRES: NA.77

属性

• 产品名称: 卡马西平, powder
• 表单: powder
• mp: 191-192 °C (lit.)
• 溶解性: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 29 mg/mL; H₂O: insoluble; ethanol: soluble; propylene glycol: soluble
• 创始人: Novartis
• 储存温度: 2-8°C
• SMILES字符串: NC(=O)N1c2ccccc2C=Cc3ccccc13
• InChI: 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
• InChI key: FFGPTBGBLSHEPO-UHFFFAOYSA-N
• 基因信息: human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , PRNP(5621) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scn2a1(24766) , Scnn1a(25122) , Scnn1g(24768) , Slc6a1(79212)

说明

应用

Carbamazepine has been used to investigate its behavior in wastewater treatment and during groundwater infiltration.[1] It has also been used to find out its effects on spontaneous seizures in rats.[2]

生化/生理作用

抗惊厥药；GABA_A受体苯二氮卓调节位点的配体。钠离子通道抑制剂。

Carbamazepine is considered as a safe antiepileptic drug. It decreases the multiple drug therapy and maintains a better control of epilepsy.[3]

特点和优势

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H302,H317,H334,H336,H360FD
• 预防措施声明: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• 危险分类: Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3
• 靶器官: Central nervous system
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Faceshields, Gloves