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Merck

F5013

Sigma-Aldrich

5-氟乳清酸 水合物

≥98%

别名:

2,6-二羟基-5-氟嘧啶-4-羧酸, 5-氟尿嘧啶-4-羧酸

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About This Item

经验公式(希尔记法):
C5H3FN2O4 · xH2O
分子量:
174.09 (anhydrous basis)
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

生物源

synthetic

品質等級

化驗

≥98%

形狀

powder

技術

cell culture | plant: suitable

mp

278 °C (dec.) (lit.)

溶解度

4 M NH4OH: 50 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]

InChI

1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2

InChI 密鑰

LODRRYMGPWQCTR-UHFFFAOYSA-N

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應用

5-氟乳清酸水合物也已用作反向筛选剂,用于筛选乳酸乳球菌(多种)肽酶敲除突变体和白色念珠菌。它已用于合成5-氟乳清苷5′-单磷酸(FOMP)。
可用于选择酿酒酵母的乳清苷-5′-磷酸脱羧酶突变体。

生化/生理作用

5-氟乳清酸是哺乳动物中rRNA合成的选择性抑制剂。

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Inhibition of ribosomal ribonucleic acid maturation in rat liver by 5-fluoroorotic acid resulting in the selective labeling of cytoplasmic messenger ribonucleic acid
Wilkinson D S, et al.
The Journal of Biological Chemistry, 246(21), 6418-6427 (1971)
Chenxi Huang et al.
Applied and environmental microbiology, 86(18) (2020-07-19)
Large-scale mass spectrometry-based peptidomics for bioactive-peptide discovery is relatively unexplored because of challenges in intracellular peptide extraction and small-peptide identification. Here, we present an analytical pipeline for large-scale intracellular peptidomics of Lactococcus lactis It entails an optimized sample preparation protocol
Lakshmi Sreekumar et al.
Genetics, 212(4), 1121-1132 (2019-05-31)
The diploid budding yeast Candida albicans harbors unique CENPA-rich 3- to 5-kb regions that form the centromere (CEN) core on each of its eight chromosomes. The epigenetic nature of these CENs does not permit the stabilization of a functional kinetochore
Mechanism of the orotidine 5?-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants
Wood B M, et al.
Biochemistry, 48(24), 5510-5517 (2009)
Jiaxin Gao et al.
Nature communications, 9(1), 4495-4495 (2018-10-31)
Fungal infections by drug-resistant Candida albicans pose a global public health threat. However, the pathogen's diploid genome greatly hinders genome-wide investigations of resistance mechanisms. Here, we develop an efficient piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans to conduct

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