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Merck

A4544

Sigma-Aldrich

L -抗坏血酸

suitable for cell culture, suitable for plant cell culture, ≥98%

别名:

维他命C, 抗坏血病因子, 维生素C

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About This Item

经验公式(希尔记法):
C6H8O6
CAS号:
分子量:
176.12
Beilstein:
84272
EC 号:
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
NACRES:
NA.21
价格与库存信息目前不能提供

质量水平

方案

≥98%

表单

powder

分子量

Mw 176.12 g/mol

技术

cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white to light yellow

pH值(酸碱度)

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

溶解性

water: soluble 50 mg/mL

SMILES字符串

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

基因信息

human ... SLC23A2(9962)

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一般描述

L-抗坏血酸又称为维生素C,是一种水溶性维生素,在各种生化反应中起还原剂的作用。抗坏血酸在胶原的合成中起到关键作用。抗坏血酸对神经发育、神经递质合成和调节神经元突触至关重要。[1]膳食维生素C缺乏会对认知能力有负面影响。[2]

应用

L-抗坏血酸已被用作牛乳腺上皮细胞[3] 和卵母细胞-颗粒细胞复合物基础培养基的成分。[4]它已被用作成骨培养基中成骨分化的补充物。[5][6]

生化/生理作用

抗坏血酸,也称为维生素C,是由植物和一些动物物种产生的六碳内酯,但人类和其他灵长类动物不能产生。抗坏血酸作为多种酶的酶促辅助因子发挥作用,用作单加氧酶和双加氧酶的电子供体。抗坏血酸也是一种强大的抗氧化剂,尤其是对活性氧类。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Mitochondrial dysfunction of in vitro grown rabbit oocytes results in preimplantation embryo arrest after activation
Kanaya H, et al.
Journal of Reproduction and Development, 53(3), 631-637 (2007)
Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Wystrychowski W, et al.
Stem Cell Research & Therapy, 7(1), 84-84 (2016)
The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts
Korda M, et al.
Tissue Engineering: Part A, 16(2), 675-683 (2009)
Does vitamin C deficiency affect cognitive development and function?
Hansen SN, et al.
Nutrients, 6(9), 3818-3846 (2014)
Vitamin C status and cognitive function: A systematic review
Travica N, et al.
Nutrients, 9(9), 960-960 (2017)

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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can we store vitamin C solution (25mM) at -20 degree? In case for how many time it can be stored?

    1 answer
    1. The solution stability of this compound has not been determined, however it is subject to degradation when exposted to oxygen or alkaline pH conditions. As a general rule, avoid repeated freeze/thaw cycles. The publication below indicates that the material is stable when stored frozen in RPMI-1640 at -20°C.
      https://pubmed.ncbi.nlm.nih.gov/1698293/

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