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Merck
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文件

S4572

Sigma-Aldrich

SANT-1 型

≥98% (HPLC), powder, SHH antagonist

别名:

（4-苄基-哌嗪-1-基）-（3,5-二甲基-1-苯基-1H-吡唑-4-基亚甲基）-胺

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About This Item

经验公式（希尔记法）:
C23H27N5
CAS号:
304909-07-7
分子量:
373.49
MDL號碼:
MFCD01827306
分類程式碼代碼:
51111800
PubChem物質ID:
329824548
NACRES:
NA.77

product name

SANT-1 型, ≥98% (HPLC), powder

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4

InChI

1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+

InChI 密鑰

FOORCIAZMIWALX-JJIBRWJFSA-N

應用

使用 SANT-1 处理间变性淋巴瘤激酶（ALK）阳性间变性大细胞淋巴瘤细胞 2 和慢性淋巴细胞白血病细胞 3 会导致细胞死亡。

生化／生理作用

SANT-1 在胶质母细胞瘤细胞中通过 Ras/NF-κB 途径抑制 Sonic hedgehog 信号传导，并诱导细胞凋亡。
SANT-1 是一种有效的 sonic hedgehog 信号途径（Shh）拮抗剂，通过与平滑（Smo）受体结合直接抑制。SANT-1 抑制野生型和致癌 Smo 的效率相同。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
Felicia W Pagliuca et al.
Cell, 159(2), 428-439 (2014-10-11)
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes. However, insulin-producing cells previously generated from human pluripotent stem cells (hPSC) lack many
P Desch et al.
Oncogene, 29(35), 4885-4895 (2010-07-07)
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members
Kathryn F Cogger et al.
Nature communications, 8(1), 331-331 (2017-08-25)
PDX1
Bushra Memon et al.
Stem cell research & therapy, 9(1), 15-15 (2018-01-25)
Pancreatic progenitors (PPs) co-expressing the two transcription factors (TFs) PDX1 and NKX6.1 are recognized as the indispensable precursors of functional pancreatic β cells. Here, we aimed to establish an efficient protocol for maximizing generation of PDX1 In order to enhance
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