8.52418

Fmoc-Asp(OBno)-OH

for peptide synthesis, Novabiochem^®

• 别名: Fmoc-Asp(OBno)-OH
• 经验公式（希尔记法）: C₃₂H₄₃NO₆
• 分子量: 537.69
• UNSPSC代码: 12352209
• NACRES: NA.22

属性

• 产品名称: Fmoc-Asp(OBno)-OH, Novabiochem^®
• 质量水平: 200
• 产品线: Novabiochem^®
• 表单: powder
• 反应适用性: reaction type: Fmoc solid-phase peptide synthesis
• 制造商/商品名称: Novabiochem^®
• 应用: peptide synthesis
• 官能团: carboxylic acid
• 储存温度: −20°C (−15°C to −25°C)

说明

一般描述

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS, including those containing the Asp-Gly sequence. The bulky OBno protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group.^,

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS

Literature references:
^[1] R. Behrendt, et al. (2015) J. Pept. Sci., 21, 680.
^[2] R. Behrendt, et al. (2016) J. Pept. Sci., 22, 92.

应用

Recently, Fmoc-Asp(OBno)-OH has been used in the synthesis of the mini-protein Omomyc, which has been shown to repress MYC-dependent gene transcription.,

分析说明

Color (visual): white to beige
Appearance of substance (visual): powder, chunks or crystals
Identity (IR): passes test
Purity (TLC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable