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Merck

M2780

Sigma-Aldrich

N 6 -甲基腺苷 5′-单磷酸 钠盐

≥97% (HPLC)

别名:

6-Me-5′-AMP, N-甲基-5′-腺苷酸二钠盐

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About This Item

线性分子式:
C11H15N5O7PNa
CAS号:
分子量:
383.23
分類程式碼代碼:
41106305
PubChem物質ID:
价格与库存信息目前不能提供

品質等級

化驗

≥97% (HPLC)

儲存溫度

−20°C

SMILES 字串

[Na].CNc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(O)C3O

InChI

1S/C11H16N5O7P.2Na/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(23-11)2-22-24(19,20)21;;/h3-5,7-8,11,17-18H,2H2,1H3,(H,12,13,14)(H2,19,20,21);;/q;2*+1/p-2/t5-,7-,8-,11-;;/m1../s1

InChI 密鑰

HFOKUKRAZPHTHH-LYYWGVPGSA-L

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應用

N6-甲基腺苷 5′-单磷酸钠盐可以用于N6-甲基腺苷(m6A) 核糖核蛋白酶免疫沉淀反应。[1]m6A在近几年获得了许多关注,因为m6A mRNA修饰在mRNA稳定和转译效率中起到作用。[2][3]

生化/生理作用

一种糖原磷酸化酶 b 活化剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.
Fry N J, et al.
RNA, 23(9), 1444-1455 (2017)
M Morange et al.
European journal of biochemistry, 65(2), 553-563 (1976-06-01)
A series of AMP analogs has been selected in order to better understand the structural requirements (a) for the efficient binding of the activator molecule at the correct site on phosphorylase b from rabbit skeletal muscle and (b) for the
N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Wang X, et al.
Cell, 161(6), 1388-1399 (2015)
Fengchao Lang et al.
PLoS pathogens, 15(6), e1007796-e1007796 (2019-06-22)
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV
Chenglei Wu et al.
Science advances, 6(34), eaba0647-eaba0647 (2020-09-03)
While N 6-methyladenosine (m6A) is the most prevalent modification of eukaryotic messenger RNA (mRNA) involved in various cellular responses, its role in modulating bacteria-induced inflammatory response remains elusive. Here, we showed that loss of the m6A reader YTH-domain family 2

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