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About This Item
经验公式（希尔记法）:
C11H18N5O14P3 · xNa+
CAS号:
分子量:
537.21 (free acid basis)
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51
推荐产品
生物源
natural (inorganic)
化驗
≥85% (HPLC)
形狀
powder
儲存溫度
−20°C
SMILES 字串
[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
InChI
1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
InChI 密鑰
FSMRTZAMTMQMEF-OCMBMSOASA-M
一般說明
7-甲基鸟苷5-′三磷酸是mRNA帽结构类似物。
應用
7-甲基鸟苷5′-三磷酸盐 (m7GTP) 被用来在 mRNA 参与蛋白质合成的背景下研究真核细胞 mRNA 帽的结构和机制。m7GTP 可用于产生捕获和纯化分子（如真核起始因子 eIF4E）的亲和介质。
7-甲基鸟苷5′-三磷酸钠盐已被用于通过荧光滴定法测试其对多聚（A）特异性核糖核酸酶（PARN）多肽的亲和力。它也与gemin5片段（G5N）和人La相关15蛋白1（LARP1）的DM15区一起用于结晶。
生化／生理作用
7-M甲基鸟苷 5′-三磷酸盐 (m7GTP) 通过结合翻译起始复合物抑制体外蛋白质合成。m7GTP用于在mRNA参与蛋白质合成的背景下研究真核细胞mRNA帽的结构和机制。m7GTP对真核起始因子eIF4E有很高的亲和力并可用于产生捕获和纯化起始因子的亲和介质。
Ya-Jun Wang et al.
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Influenza virus, which spreads around the world in seasonal epidemics and leads to large numbers of deaths every year, has several ribonucleoproteins in the central core of the viral particle. These viral ribonucleoproteins can specifically bind the conserved 3' and
Regina Cencic et al.
Analytical biochemistry, 560, 24-29 (2018-09-09)
All cellular cytoplasmic mRNAs are capped at their 5' ends with an m7GpppN group. Several proteins that mediate cap function have been identified by cap affinity purification, enabling their characterization in a number of biological processes. Among these, eukaryotic initiation
Weijia Cai et al.
Oncotarget, 5(15), 6015-6027 (2014-06-28)
The cap-dependent translation is frequently deregulated in a variety of cancers associated with tumor progression. However, the molecular basis of the translation activation for metastatic progression of cancer remains largely elusive. Here, we demonstrate that activation of cap-dependent translation by
Applications of phosphate modification and labeling to study (m) RNA caps
Warminski M, et al.
Topics in Current Chemistry, 211-239 (2017)
Ricardo Soto-Rifo et al.
Nucleic acids research, 41(12), 6286-6299 (2013-05-01)
Here, we show a novel molecular mechanism promoted by the DEAD-box RNA helicase DDX3 for translation of the HIV-1 genomic RNA. This occurs through the adenosine triphosphate-dependent formation of a translation initiation complex that is assembled at the 5' m(7)GTP
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